16726-41-3

Basic information

• Product Name: ISOPROPYLHYDRAZINE HYDROCHLORIDE
• Synonyms: ISOPROPYLHYDRAZINE HYDROCHLORIDE;isopropylhydrazine monohydrochloride;Einecs 240-784-3;Hydrazine, (1-methylethyl)-, hydrochloride (1:1);Hydrazine, (1-methylethyl)-, monohydrochloride;Prop-2-ylhydrazine hydrochloride;ISOPROPYLHYDRAZINE DIHYDROCHLORIDE;(1-Methylethyl)hydrazine Monohydrochloride
• CAS NO: 16726-41-3
• Molecular Formula: C₃H₁₀N₂*2ClH
• Molecular Weight: 110.59
• EINECS: 240-784-3
• Product Categories: Amines;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;COOR
• Mol File: 16726-41-3.mol
• Article Data: 12

Chemical Properties

• Melting Point: 115-118
• Boiling Point: 120.1 °C at 760 mmHg
• Flash Point: 24.8 °C
• Appearance: COA
• Density: 0.815g/cm3
• Vapor Pressure: 15.5mmHg at 25°C
• Refractive Index: 1.42
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility: Soluble in water
• CAS DataBase Reference: ISOPROPYLHYDRAZINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: ISOPROPYLHYDRAZINE HYDROCHLORIDE(16726-41-3)
• EPA Substance Registry System: ISOPROPYLHYDRAZINE HYDROCHLORIDE(16726-41-3)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN2811
• HazardClass: IRRITANT
• Hazardous Substances Data: 16726-41-3(Hazardous Substances Data)

Usage

Description

Isopropylhydrazine hydrochloride is a white to almost white crystalline powder that serves as a potent monoamine oxidase inhibitor. It is a chemical compound with the molecular formula C3H10ClN3 and is known for its ability to inhibit the activity of monoamine oxidase enzymes, which are involved in the breakdown of monoamines in the body.

Uses

Used in Pharmaceutical Industry:
Isopropylhydrazine hydrochloride is used as a pharmaceutical agent for its potent monoamine oxidase inhibiting properties. It is particularly useful in the development of medications aimed at treating various conditions related to the imbalance of monoamines, such as depression, anxiety, and other mood disorders.
Used in Research and Development:
Isopropylhydrazine hydrochloride is also utilized in the research and development of new drugs and therapies. Its ability to inhibit monoamine oxidase enzymes makes it a valuable tool for studying the effects of these enzymes on various biological processes and for developing novel treatments for related conditions.
Used in Chemical Synthesis:
In addition to its pharmaceutical applications, Isopropylhydrazine hydrochloride can be used as a chemical intermediate in the synthesis of other compounds. Its unique chemical properties make it a versatile building block for creating a variety of molecules with potential applications in different industries.

InChI:InChI=1/C3H10N2/c1-3(2)5-4/h3,5H,4H2,1-2H3

Upstream product

• 16689-35-3 tert-butyl 2-(isopropyl)hydrazinecarboxylate 
• 1068-55-9 isopropylmagnesium chloride 
• 1133463-25-8 1-(isopropyl)-2-tert-butoxycarbonylhydrazine acetate 
• 175233-53-1 1-isopropylhydrazinecarboxylic acid tert-butyl ester 
• 16689-34-2 tert-butyl isopropylidenecarbazate 

Downstream Products

• 93737-04-3 Z-Leu-HN-NH-CH(CH₃)2 
• 92432-33-2 Z-Ala-HN-NH-CH(CH₃)2 
• 92432-52-5 Z-Ser-HN-NH-CH(CH₃)2 
• 133004-68-9 Z-Glu(NH₂)-HN-NH-CH(CH₃)2 
• 58605-87-1 1-cyano-1-isopropylhydrazine 
• 934406-11-8 3-bromo-N-[4-chloro-2-(N'-isopropylhydrazinocarbonyl)-6-methylphenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide 
• 1211547-87-3 1,3-diisopropyl-5-(4-methoxyphenyl)-1H-1,2,4-triazole 
• 1211547-86-2 1-isopropyl-5-(4-methoxyphenyl)-3-methyl-1H-1,2,4-triazole 
• 1211547-88-4 1-isopropyl-5-(4-methoxyphenyl)-3-phenyl-1H-1,2,4-triazole 
• 1211547-89-5 4-(1-isopropyl-5-(4-methoxyphenyl)-1H-1,2,4-triazol-3-yl)pyridine 
• 1211547-90-8 1-isopropyl-5-(4-methoxy-phenyl)-3-(2-methyl-thiazol-4-yl)-1H-[1,2,4]triazole 
• 1211547-91-9 5-(3-chlorophenyl)-1-isopropyl-3-methyl-1H-1,2,4-triazole 
• 1211547-93-1 1-isopropyl-5-(1-methyl-1H-pyrazol-4-yl)-3-phenyl-1H-1,2,4-triazole 
• 1211547-94-2 2-(1-isopropyl-3-phenyl-1H-1,2,4-triazol-5-yl)pyrazine 

Relevant articles and documents

Decarboxylative hydrazination of unactivated carboxylic acids by cerium photocatalysis

We report the cerium photocatalyzed radical decarboxylative hydrazination of carboxylic acids with di-tert-butylazodicarboxylate (DBAD). The operationally simple protocol provides rapid access to synthetically useful hydrazine derivatives and overcomes current scope limitations in the photoredox-catalyzed decarboxylation of carboxylic acids.

1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-ones as PDE1 Inhibitors

The present invention provides 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-ones of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

PYRAZOLO[3,4-D]PYRIMIDIN-4(5H)-ONE DERIVATIVES AS PDE9 INHIBITORS

A compound of the general formula (I) wherein R1 is selected from the group consisting of phenyl unsubstituted or substituted with 1 to 3 substituents selected from F, Cl, Br, I, CN, -O-C1-C3-alkyl, fluorinated -O-C1-C3-alkyl, -(CH2)mOH and 5-membered heterocyclic group with 1 or 2 heteroatoms selected from N, O and S; and 6- or 10-membered heteroaryl with 1 to 3 heteroatoms selected from O, N and S; R2 and R3 independently of each other represent H atom or straight or branched C1-C3 alkyl; R4 is selected from the group consisting of 4- to 6- membered cycloalkyl, wherein one of carbon atoms can be replaced by O atom, and which is unsubstituted or substituted with one or two halogen atoms,and straight or branched C1-C4 alkyl; Q represents a bond or C1-C3-alkylene, which can be optionally substituted by one to three C1-C3-alkyls; X is selected from the group consisting of O, NR5, and S(O)p; R5 represents H atom or C1-C3alkyl; m is 1, 2 or 3; p is 0, 1 or 2; and salts thereof, for use as a medicament, in particular for treating cognitive function disorders and neurodegenerative diseases.