167298-54-6

Basic information

• Product Name: 2-Pyridinemethanamine,6-amino-(9CI)
• Synonyms: 2-Pyridinemethanamine,6-amino-(9CI);6-(aminomethyl)pyridin-2-amine;6-amino-2-(aminomethyl)pyridine;2-Amino-6-(aminomethyl)pyridine;2-Pyridinemethanamin
• CAS NO: 167298-54-6
• Molecular Formula: C₆H₉N₃
• Molecular Weight: 123.15576
• Product Categories: PYRIDINE
• Mol File: 167298-54-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 273.1±25.0 °C(Predicted)
• Appearance: /
• Density: 1.173±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 8.80±0.39(Predicted)
• CAS DataBase Reference: 2-Pyridinemethanamine,6-amino-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinemethanamine,6-amino-(9CI)(167298-54-6)
• EPA Substance Registry System: 2-Pyridinemethanamine,6-amino-(9CI)(167298-54-6)

Safety Data

• Hazardous Substances Data: 167298-54-6(Hazardous Substances Data)

Usage

General Description

2-Pyridinemethanamine,6-amino-(9CI) is a chemical compound with the molecular formula C6H8N2. It is a derivative of pyridine and contains an amino group. 2-Pyridinemethanamine,6-amino-(9CI) is commonly used in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential applications in organic synthesis and as a building block in the production of various specialty chemicals. Additionally, 2-Pyridinemethanamine,6-amino-(9CI) has been investigated for its pharmacological properties and potential therapeutic use in the treatment of various medical conditions. Overall, this chemical compound has a wide range of potential applications and is the subject of ongoing research in the fields of chemistry and pharmacology.

Upstream product

• 1824-81-3 2-Amino-6-methylpyridine 
• 161041-55-0 2-phthalimidomethyl-6-pivalamidopyridine 
• 111477-43-1 N-(6-(bromomethyl)-2-pyridyl)pivalamide 
• 86847-79-2 2,2-dimethyl-N-(6-methylpyridin-2-yl)propanamide 
• 193470-32-5 2-(Phthalimido)methyl-6-(phthalimido)pyridine 
• 161041-56-1 N-(6-aminomethyl-pyridin-2-yl)-2,2-dimethylpropionamide 
• 127682-66-0 6-acetamidopyridine-2-carboxaldehyde 

Downstream Products

• 944112-71-4 6-[(6-amino-pyridin-2-ylmethyl)-amino]-1,3-bis-(4-methoxy-benzyl)-1H-[1,3,5]triazine-2,4-dione 
• 904686-05-1 C₁₆H₁₄ClN₃ 

Relevant articles and documents

PYRAZINE COMPOUNDS AND USES THEREOF

The present disclosure novel pyrazine compounds targeting adenosine receptors (especially A1 and A2, particularly A2a). The present disclosure also relates to pharmaceutical compositions comprising one or more of the compounds as an active ingredient, and use of the compounds in the treatment of adenosine receptor (AR) associated diseases, for example cancer such as NSCLC, RCC, prostate cancer, and breast cancer.

Novel pyrrolyl 2-aminopyridines as potent and selective human β-secretase (BACE1) inhibitors

The proteolytic enzyme β-secretase (BACE1) plays a central role in the synthesis of the pathogenic β-amyloid in Alzheimer's disease. Recently, we reported small molecule acylguanidines as potent BACE1 inhibitors. However, many of these acylguanidines have a high polar surface area (e.g. as measured by the topological polar surface area or TPSA), which is unfavorable for crossing the blood-brain barrier. Herein, we describe the identification of the 2-aminopyridine moiety as a bioisosteric replacement of the acylguanidine moiety, which resulted in inhibitors with lower TPSA values and superior brain penetration. X-ray crystallographic studies indicated that the 2-aminopyridine moiety interacts directly with the catalytic aspartic acids Asp32 and Asp228 via a hydrogen-bonding network.

PROKINETICIN 2 RECEPTOR ANTAGONISTS

The present invention relates to certain novel compounds of Formula (I): and methods for the treatment of prokineticin 2 or prokinetin 2 receptor mediated disorders.