16738-12-8

Basic information

• Product Name: Methyl 2-(naphthalen-1-yl)-2-oxoacetate
• Synonyms: Methyl 2-(naphthalen-1-yl)-2-oxoacetate
• CAS NO: 16738-12-8
• Molecular Formula: C₁₃H₁₀O₃
• Molecular Weight: 214.2167
• Mol File: 16738-12-8.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl 2-(naphthalen-1-yl)-2-oxoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(naphthalen-1-yl)-2-oxoacetate(16738-12-8)
• EPA Substance Registry System: Methyl 2-(naphthalen-1-yl)-2-oxoacetate(16738-12-8)

Safety Data

• Hazardous Substances Data: 16738-12-8(Hazardous Substances Data)

Upstream product

• 879-18-5 naphthalene-1-carbonic acid chloride 
• 18166-02-4 N-trimethylsilylmethylamine 
• 124-38-9 carbon dioxide 
• 88313-80-8 naphthalen-1-yl(trimethylsilyl)methanone 
• 5781-53-3 monomethyl oxalyl chloride 
• 91-20-3 naphthalene 
• 553-90-2 Dimethyl oxalate 
• 90-11-9 1-Bromonaphthalene 
• 67-56-1 methanol 
• 941-98-0 1'-naphthacetophenone 
• 78772-53-9 methyl 2-hydroxy-2-(naphthalen-1-yl)acetate 
• 370561-84-5 methyl 2-diazo-2-(naphthalen-1-yl)acetate 
• 13158-05-9 (+/-)-Methyl α-methoxy-α-(1-naphthyl)acetate 
• 2876-78-0 methyl 1-naphthylacetate 

Downstream Products

• 86-87-3 naphth-1-yl acetic acid 

Relevant articles and documents

Preparation method of alpha-ketoester compound

The invention discloses a preparation method of an alpha-ketone ester compound. The method specifically comprises the following operation steps: adding raw materials alpha-diazo ester and an organic photocatalyst into a reaction flask, then adding an organic solvent, and reacting for 2-12 hours in air at room temperature under the irradiation of a visible light lamp; after the reaction is monitored by thin-layer chromatography (TLC), stopping the reaction, and extracting a reaction solution by using ethyl acetate; concentrating the extracting solution under reduced pressure to obtain a crude product, and performing column chromatography separation on the crude product to obtain the alpha-diazonium ester compound. According to the preparation method, clean visible light is used as reaction energy, cheap organic dye is used as a photocatalyst, air is used as a green oxidizing agent and an oxygen source, and the preparation method has the advantages of simplicity and convenience in operation, no metal residue and mild reaction conditions.

Copper(I)-catalyzed aerobic oxidation of α-diazoesters

A practical Cu-catalyzed oxidation of α-diazoesters to α-ketoesters using molecular oxygen as an oxidant has been developed. Both electron-poor and electron-rich aryl α-diazoesters are suitable substrates and provide the α-ketoesters in good yields. In this oxidative system, α-diazo-β-ketoesters are also compatible as substrates but unexpectedly furnish α-ketoesters via C-C bond cleavage, rather than the vicinal tricarbonyl products.

CuO-catalyzed oxidation of aryl acetates with aqueous tert-butyl hydroperoxide for the synthesis of α-ketoesters

A practical method to access α-ketoesters from readily available aryl acetates is developed. In this approach, aqueous tert-butyl hydroperoxide and CuO are employed. No additional solvents are required and it was found that the peroxide side products in the reaction can be decomposed by pyridine.