167409-41-8

Basic information

• Product Name: 2-cyanoethyl 2-(nicotinoylamino)ethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
• Synonyms: 2-cyanoethyl 2-(nicotinoylamino)ethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
• CAS NO: 167409-41-8
• Molecular Weight: 519.514
• Mol File: 167409-41-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-cyanoethyl 2-(nicotinoylamino)ethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyanoethyl 2-(nicotinoylamino)ethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate(167409-41-8)
• EPA Substance Registry System: 2-cyanoethyl 2-(nicotinoylamino)ethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate(167409-41-8)

Safety Data

• Hazardous Substances Data: 167409-41-8(Hazardous Substances Data)

Upstream product

• 129904-65-0 2-(nicotinoylamino)ethyl acetoacetate 
• 6265-73-2 N-(2-hydroxyethyl)nicotinamide 
• 93-60-7 methyl 3-pyridinecarboxylate 
• 193539-61-6 (Z)-3-Amino-but-2-enoic acid 2-cyano-ethyl ester 
• 92565-05-4 2-(nicotinoylamino)ethyl 2-(3-nitrobenzylidene)acetoacetate 
• 99-61-6 3-nitro-benzaldehyde 
• 65193-87-5 2-cyanoethylacetoacetate 
• 154049-22-6 2-(nicotinoylamino)ethyl-3-aminocrotonate 

Downstream Products

• 129904-66-1 2,6-dimethyl4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(2-nicotinoylaminoethyl) ester 

Relevant articles and documents

Mild and facile cleavage of 2-cyanoethyl ester using sodium sulfide or tetrabutylammonium fluoride. Synthesis of 1,4-dihydropyridine monocarboxylic acids and unsymmetrical 1,4-dihydropyridine dicarboxylates

Several 3-(2-cyanoethyl)-1,4-dihydropyridine carboxylates (16) were prepared in moderate to good yields by means of the Hantzsch reaction. Treatment of these carboxylates with a weak base such as sodium sulfide or tetrabutylammonium fluoride at room temperature afforded smoothly the corresponding 1,4-dihydropyridine monocarboxylic acids (18) in good yields. The monocarboxylic acids 18n and 18o were esterified with 2-nitrooxypropanol or N-(2-hydroxyethyl)nicotinamide p-toluenesulfonic acid salt to afford the selective coronary vasodilators CD-349 (5) and CD-832 (6), respectively.