167479-78-9 Usage
Description
L-4-Cyanophenylalanine, also known as 4-Cyano-L-phenylalanine, is an amino acid derivative with a cyano group (CN) attached to the para position of the phenyl ring. It is a crucial building block in the synthesis of various organic compounds, pharmaceuticals, and has significant applications in chemical research and biochemical applications.
Uses
Used in Organic Synthesis:
L-4-Cyanophenylalanine is used as an intermediate in organic synthesis for the production of various complex molecules and compounds. Its unique structure allows for a wide range of reactions, making it a valuable component in the creation of novel organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, L-4-Cyanophenylalanine is utilized as a key intermediate in the development of new drugs. Its incorporation into drug molecules can lead to improved pharmacological properties, such as enhanced potency, selectivity, and bioavailability.
Used in Chemical Research:
L-4-Cyanophenylalanine plays a significant role in chemical research, where it is employed to study the properties and reactivity of various chemical compounds. Its unique structure allows researchers to gain insights into the behavior of different molecules and develop new synthetic strategies.
Used in Biochemical Applications:
In the field of biochemistry, L-4-Cyanophenylalanine is used as a building block for the synthesis of peptides and proteins with altered properties. Its incorporation into biologically active molecules can lead to the development of new bioactive compounds with potential applications in medicine and biotechnology.
Check Digit Verification of cas no
The CAS Registry Mumber 167479-78-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,7,4,7 and 9 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 167479-78:
(8*1)+(7*6)+(6*7)+(5*4)+(4*7)+(3*9)+(2*7)+(1*8)=189
189 % 10 = 9
So 167479-78-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H10N2O2/c11-6-8-3-1-7(2-4-8)5-9(12)10(13)14/h1-4,9H,5,12H2,(H,13,14)/t9-/m0/s1
167479-78-9Relevant articles and documents
The bacterial ammonia lyase EncP: A tunable biocatalyst for the synthesis of unnatural amino acids
Weise, Nicholas J.,Parmeggiani, Fabio,Ahmed, Syed T.,Turner, Nicholas J.
supporting information, p. 12977 - 12983 (2015/10/28)
Enzymes of the class I lyase-like family catalyze the asymmetric addition of ammonia to arylacrylates, yielding high value amino acids as products. Recent examples include the use of phenylalanine ammonia lyases (PALs), either alone or as a gateway to deracemization cascades (giving (S)- or (R)-α-phenylalanine derivatives, respectively), and also eukaryotic phenylalanine aminomutases (PAMs) for the synthesis of the (R)-β-products. Herein, we present the investigation of another family member, EncP from Streptomyces maritimus, thereby expanding the biocatalytic toolbox and enabling the production of the missing (S)-β-isomer. EncP was found to convert a range of arylacrylates to a mixture of (S)-α- and (S)-β-arylalanines, with regioselectivity correlating to the strength of electron-withdrawing/-donating groups on the ring of each substrate. The low regioselectivity of the wild-type enzyme was addressed via structure-based rational design to generate three variants with altered preference for either α- or β-products. By examining various biocatalyst/substrate combinations, it was demonstrated that the amination pattern of the reaction could be tuned to achieve selectivities between 99:1 and 1:99 for β:α-product ratios as desired.
Fluorobenzamidrazone thrombin inhibitors: Influence of fluorine on enhancing oral absorption
Lee, Koo,Jung, Won-Hyuk,Sang, Yeul Hwang,Lee, Sung-Hack
, p. 2483 - 2486 (2007/10/03)
LB30057 (1) is a selective and efficacious oral thrombin inhibitor. Fluorine-substitution on the phenylene ring of the benzamidrazone portion in both compound 1 and its derivatives gave, in many cases, enhanced oral absorption in rats while maintaining the intrinsic potency and selectivity. Compound 2 demonstrated a 3-fold increase in absorption.
