167637-35-6

Basic information

• Product Name: 4-[(2E,4E)-3-Methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-2,4-dien-(Z)-ylidene]-5,6,7,8-tetrahydro-4H-isochromene-1,3-dione
• Synonyms: 4-[(2E,4E)-3-Methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-2,4-dien-(Z)-ylidene]-5,6,7,8-tetrahydro-4H-isochromene-1,3-dione
• CAS NO: 167637-35-6
• Molecular Weight: 366.5
• Mol File: 167637-35-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[(2E,4E)-3-Methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-2,4-dien-(Z)-ylidene]-5,6,7,8-tetrahydro-4H-isochromene-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(2E,4E)-3-Methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-2,4-dien-(Z)-ylidene]-5,6,7,8-tetrahydro-4H-isochromene-1,3-dione(167637-35-6)
• EPA Substance Registry System: 4-[(2E,4E)-3-Methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-2,4-dien-(Z)-ylidene]-5,6,7,8-tetrahydro-4H-isochromene-1,3-dione(167637-35-6)

Safety Data

• Hazardous Substances Data: 167637-35-6(Hazardous Substances Data)

Upstream product

• 56955-19-2 ethyl 2-(2-oxo-1-cyano-2-ethoxyethylidene)-cyclohexanecarboxylate 
• 3917-41-7 (2E,4E)-3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienal 
• 3711-74-8 5,6,7,8-tetrahydro-4H-isochromene-1,3-dione 

Relevant articles and documents

Evaluation of retinoid lactones as topical therapeutic agents in dermatology

Purpose. Optimization of the therapeutic ratio of analogs of the topically active 11-cis,13-cis-12-hydroxymethylretinoic acid, δ-lactone (I) relative to antihyperproliferation and antihyperkeratinization vs. toxicity. Methods. Nine analogs of 1, in which variations were made in the lipophilic cyclohexenyl moiety or in the lactone ring, were evaluated for topical activity against hyperkeratinization, inhibition of TPA-induced DNA synthesis and for skin irritation. Results. Although more potent lactones than the parent lactone 1 were identified, none possessed the favorable therapeutic ratio associated with 1. Conclusions. The δ-lactone 1 possesses unique molecular features responsible for its desirable therapeutic ratio as an anti-hyperproliferative and antihyperkeratotic agent. In view of its very low systemic retinoid toxicity and the absence of any systemic toxicity, this lactone may be a good candidate for use in the topical treatment of acne.