167705-56-8

Basic information

• Product Name: 2-Phenyl-1-(phenylmethyl)-4-piperidinone
• Synonyms: 2-Phenyl-1-(phenylmethyl)-4-piperidinone;N-Benzyl-2-phenyl-4-piperidinone;1-Benzyl-2-phenylpiperidin-4-one
• CAS NO: 167705-56-8
• Molecular Formula: C₁₈H₁₉NO
• Molecular Weight: 265
• Mol File: 167705-56-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 409.7±33.0 °C(Predicted)
• Appearance: /
• Density: 1.121
• Storage Temp.: 2-8°C
• PKA: 6.32±0.40(Predicted)
• CAS DataBase Reference: 2-Phenyl-1-(phenylmethyl)-4-piperidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenyl-1-(phenylmethyl)-4-piperidinone(167705-56-8)
• EPA Substance Registry System: 2-Phenyl-1-(phenylmethyl)-4-piperidinone(167705-56-8)

Safety Data

• Hazardous Substances Data: 167705-56-8(Hazardous Substances Data)

Usage

General Description

2-Phenyl-1-(phenylmethyl)-4-piperidinone, which can also be known as 1-Benzyl-2-phenyl-4-piperidinone, is a chemical compound in the category of piperidinones. Its molecular formula is C18H19NO and it has a molecular weight of 267.35 g/mol. 2-Phenyl-1-(phenylmethyl)-4-piperidinone is generally known for its use in chemical synthesis and is usually handled and stored in a controlled environment due to potential health hazards associated. It can cause eye, skin, and respiratory irritation on exposure. Hence, it should be manipulated with appropriate protective measures. It is recommended for research and development applications only.

InChI:InChI=1S/C18H19NO/c20-17-11-12-19(14-15-7-3-1-4-8-15)18(13-17)16-9-5-2-6-10-16/h1-10,18H,11-14H2

Upstream product

• 100-52-7 benzaldehyde 
• 78-94-4 methyl vinyl ketone 
• 100-46-9 benzylamine 
• 152873-62-6 N-benzyl-2,3-dihydro-2-phenyl-1H-pyridin-4-one 
• 780-25-6 N-benzylidene benzylamine 
• 4393-14-0 N-methylenebenzylamine 
• 73400-25-6 {(1E)-3-[(trimethylsilyl)oxy]buta-1,3-dien-1-yl}benzene 
• 824938-70-7 (E)-5-(benzylamino)-1-phenyl-1-penten-3-one 

Relevant articles and documents

Synthetic applications of 2-aryl-4-piperidones. X. Synthesis of 3-aminopiperidines, potential substance P antagonists

A general method is described for the synthesis of 3-aminopiperidines from 4-piperidones based on a KOEt treatment of the tosylate of the corresponding oximes (Neber rearrangement). The procedure is applied to the synthesis of N-benzyl-3-amino-4,4-diethoxypiperidine (13), (R)-N-(2-hydroxy-1-phenyl)ethyl analogues 18, and 2-phenyl derivatives 27-28. The methoxybenzylation of the primary amino group of these aminopiperidines leads to a series of potential substance P antagonists.

A two-step, formal [4 + 2] approach toward piperidin-4-ones via au catalysis

(Chemical Equation Presented) An efficient, formal [4 + 2] synthesis of synthetically valuable piperidin-4-ones from secondary amines in two steps has been achieved via a key gold catalysis without the purification of tertiary amine intermediates. This reaction is selective toward the less-substituted alkyl group and shows moderate to excellent diastereoselectivities. Its synthetic potential in alkaloid synthesis is demonstratedin a highly diastereoselective synthesis of (±)-cermizine C.

Combinatorial synthesis of dihydropyridone libraries and their derivatives

Polymer-supported quench methodology has been used for parallel purification of combinatorial libraries of dihydropyridones and their derivatives. The dihydropyridone scaffold was assembled via a solution phase Lewis acid catalyzed, hetero-Diels-Alder reaction. Further modifications allow for the rapid generation of subsequent aminopiperidine and acylaminopiperidine libraries utilizing a library from library approach.