167757-46-2

Basic information

• Product Name: benzyl 4-[amino(thiocarbonyl)]piperidine-1-carboxylate
• Synonyms: benzyl 4-[amino(thiocarbonyl)]piperidine-1-carboxylate;Piperidine-4-thiocarboxamide, N1-CBZ protected;Piperidine-4-thiocarboxamide, N1-CBZ protected 97%;N1-CBZ-PIPERIDINE-4-THIOCARBOXAMIDE;Benzyl 4-(Aminocarbonothioyl)-piperidine-1-carboxylate;Piperidine-4-thiocarboxamide,N1-CBZprotected97%;Benzyl 4-carbamothioylpiperidine-1-carboxylate;Benzyl 4-[Amino(Thiocarbonyl)]Piperidine-1-Carboxylate(WX619901)
• CAS NO: 167757-46-2
• Molecular Formula: C₁₄H₁₈N₂O₂S
• Molecular Weight: 278.36992
• Mol File: 167757-46-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 128 °C
• Boiling Point: 441.9 °C at 760 mmHg
• Flash Point: 221.1 °C
• Appearance: /
• Density: 1.253g/cm³
• Vapor Pressure: 5.24E-08mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: 2-8°C
• CAS DataBase Reference: benzyl 4-[amino(thiocarbonyl)]piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 4-[amino(thiocarbonyl)]piperidine-1-carboxylate(167757-46-2)
• EPA Substance Registry System: benzyl 4-[amino(thiocarbonyl)]piperidine-1-carboxylate(167757-46-2)

Safety Data

• Hazard Codes: Harmful:
• Hazardous Substances Data: 167757-46-2(Hazardous Substances Data)

Usage

Description

Benzyl 4-[amino(thiocarbonyl)]piperidine-1-carboxylate is a complex chemical compound that features a benzene ring connected to a piperidine ring. This structure is further characterized by the presence of an amino group and a thiocarbonyl group attached to the piperidine ring, along with a carboxylic acid group. benzyl 4-[amino(thiocarbonyl)]piperidine-1-carboxylate may serve various roles in different chemical contexts, including organic synthesis, pharmaceutical research, or as a component in the creation of other chemical entities.

Uses

Used in Organic Synthesis:
Benzyl 4-[amino(thiocarbonyl)]piperidine-1-carboxylate is utilized as a synthetic intermediate for the development of more complex organic molecules. Its unique structure allows it to participate in a variety of chemical reactions, facilitating the formation of new compounds with potential applications across various industries.
Used in Pharmaceutical Research:
In the pharmaceutical industry, benzyl 4-[amino(thiocarbonyl)]piperidine-1-carboxylate is employed as a building block for the design and synthesis of new drugs. Its versatile chemical properties make it a valuable component in the creation of molecules with potential therapeutic effects.
Used in Chemical Compound Development:
Benzyl 4-[amino(thiocarbonyl)]piperidine-1-carboxylate also serves as a key component in the development of new chemical compounds. Its presence in these compounds can impart specific properties that are desirable for particular applications, such as improved stability, reactivity, or selectivity in chemical processes.

InChI:InChI=1/C14H18N2O2S/c15-13(19)12-6-8-16(9-7-12)14(17)18-10-11-4-2-1-3-5-11/h1-5,12H,6-10H2,(H2,15,19)

Upstream product

• 19172-47-5 Lawessons reagent 
• 167757-45-1 4-Carbamoylpiperidine-1-carboxylic acid benzyl ester 
• 39546-32-2 4-carboxamidopiperidine 
• 1885-14-9 phenyl chloroformate 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 866785-62-8 C₁₆H₁₈N₂O₂S 
• 1394939-79-7 benzyl-4-[4-(3-{[(2,5-difluorophenyl)sulfonyl](methoxymethyl)amino}-2-fluorophenyl)-5-(pyridin-4-yl)-1,3-thiazol-2-yl]piperidine-1-carboxylate 
• 1394938-39-6 2,5-difluoro-N-{2-fluoro-3-[2-(1-methylpiperidin-4-yl)-5-(pyridin-4-yl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide 
• 189695-66-7 2-[1-(phenylmethoxycarbonyl)-4-piperidyl]-4-ethoxycarbonyl-1,3-thiazole 

Relevant articles and documents

THIAZOLYLPHENYL-BENZENESULFONAMIDO DERIVATIVES AS KINASE INHIBITORS

Thiazolylphenyl-benzenesulfonamido derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

5-membered heterocycles, medicaments containing these compounds, their use and processes for their preparation

5-Membered heterocyclic compounds, of which the following compounds are exemplary: (a) 4-??trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-1-(4-piperidyl)imidazole, (b) 5-??trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-4-methyl-2-(4-piperidyl)-1,3-thiazole, (c) 5-??4-(carboxymethoxy)phenyl!aminocarbonyl!-4-methyl-2-(4-piperidyl)-1,3-thiazole, (d) 5-??trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-2-(4-piperidyl)-1,3,4-thiadiazole, (e) 5-??4-(carboxymethoxy)phenyl!aminocarbonyl!-2-(4-piperidyl)-1,3,4-thiadiazole, (f) 5-??trans-4-(carboxymethoxy)cyclohexyl!aminocarbonyl!-2-(4-piperidyl)-1,3-thiazole, (g) 5-??4-(carboxymethoxy)phenyl!aminocarbonyl!-2-(4-piperidyl)-1,3-thiazole, (h) 5-??trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-2-(4-piperidyl)-1,3-thiazole, and (i) 4-??trans-4-carboxycyclohexyl!aminocarbonyl!-1-?2-(4-piperidyl)ethyl!imidazole. These are useful for the treatment or prevention of illnesses in which relatively small or relatively large cell aggregates occur or cell-matrix interactions play a part.