167983-27-9

Basic information

• Product Name: [(S)-3-Methyl-1-(2-oxo-2-phenyl-ethylcarbamoyl)-butyl]-carbamic acid benzyl ester
• CAS NO: 167983-27-9
• Molecular Weight: 382.459
• Mol File: 167983-27-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [(S)-3-Methyl-1-(2-oxo-2-phenyl-ethylcarbamoyl)-butyl]-carbamic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(S)-3-Methyl-1-(2-oxo-2-phenyl-ethylcarbamoyl)-butyl]-carbamic acid benzyl ester(167983-27-9)
• EPA Substance Registry System: [(S)-3-Methyl-1-(2-oxo-2-phenyl-ethylcarbamoyl)-butyl]-carbamic acid benzyl ester(167983-27-9)

Safety Data

• Hazardous Substances Data: 167983-27-9(Hazardous Substances Data)

Upstream product

• 2018-66-8 Z-Leu-OH 
• 613-89-8 2-Aminoacetophenone 

Downstream Products

• 167983-28-0 (S)-benzyl 3-methyl-1-(4-phenyl-1H-imidazol-2-yl)butylcarbamate 

Relevant articles and documents

Design, synthesis, activity, and structure of a novel class of matrix metalloproteinase inhibitors containing a heterocyclic P'2-P'3 amide bond isostere

A novel series of hydroxamate-based inhibitors of matrix metalloproteinases containing benzimidazole and imidazole heterocycles as amide bond isosteres have been prepared. Potent inhibition (in the low nanomolar range) and selectivity (> 100-fold) can be attained with inhibitors containing only one amide bond. X-ray crystal structures of matrilysin (MMP- 7) with two different inhibitors bound confirm that imidazole is an excellent amide bond isostere.