168112-44-5

Basic information

• Product Name: Oxazole, 4,5-dihydro-4-methyl-2,5-diphenyl-, (4R,5R)-
• CAS NO: 168112-44-5
• Molecular Formula: C16H15NO
• Molecular Weight: 237.301
• Mol File: 168112-44-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Oxazole, 4,5-dihydro-4-methyl-2,5-diphenyl-, (4R,5R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Oxazole, 4,5-dihydro-4-methyl-2,5-diphenyl-, (4R,5R)-(168112-44-5)
• EPA Substance Registry System: Oxazole, 4,5-dihydro-4-methyl-2,5-diphenyl-, (4R,5R)-(168112-44-5)

Safety Data

• Hazardous Substances Data: 168112-44-5(Hazardous Substances Data)

Upstream product

• 126524-00-3 erythro (1S,2R)-1-phenyl-2-benzamido-1-propanol 
• 157903-42-9 threo (1R,2R)-1-phenyl-2-benzamido-1-propanol 
• 873-66-5 1-propenylbenzene 
• 98-88-4 benzoyl chloride 
• 37577-07-4 Norpseudoephedrine 
• 37577-28-9 (1S,2R)-(+)-norphedrine 

Downstream Products

• 37577-07-4 Norpseudoephedrine 

Relevant articles and documents

SYNTHESIS OF OXAZOLINE COMPOUNDS

The present invention provides an improved process for preparing an oxazoline compound of the formula: (I) wherein R1 and R2 are independently hydrogen, sulfide, sulfoxide, sulfonyl, optionally substituted lower alkyl, optionally sub

THERMAL CYCLIZATION OF Β-HYDROXYAMIDES TO OXAZOLINES

Thermal conversion of amides derived from erythro and threo ephedrines yields stereospecific oxazolines.

(DIETHYLAMINO)SULFUR TRIFLUORIDE (DAST) AS A USEFUL REAGENT FOR THE PREPARATION OF 2-OXAZOLINES FROM 1,2-AMIDO ALCOHOLS

Acylic 1,2-amido alcohols (6) react efficiently with a slight excess of (diethylamino)sulfur trifluoride (DAST) to afford the corresponding 2-oxazolines (10) in good yields ranging between 57-95percent.Even at the low temperature of -78 deg C, a rapid ( 1 h) and stereoselective amide cyclization is observed without formation of acylaziridine by-products.The scope of this cyclization is discussed.