16819-79-7

Basic information

• Product Name: 2'-ETHYLPROPIOPHENONE
• Synonyms: 2'-ETHYLPROPIOPHENONE;ETHYL 2-ETHYLPHENYL KETONE;Ethylpropiophenone;2'-ETHYLPROPIOPHENONE 97+%;1-(2-ethylphenyl)propan-1-one;1-Propanone,1-(2-ethylphenyl)-
• CAS NO: 16819-79-7
• Molecular Formula: C₁₁H₁₄O
• Molecular Weight: 162.23
• Mol File: 16819-79-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 250.2±19.0 °C(Predicted)
• Appearance: /
• Density: 0.98
• CAS DataBase Reference: 2'-ETHYLPROPIOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-ETHYLPROPIOPHENONE(16819-79-7)
• EPA Substance Registry System: 2'-ETHYLPROPIOPHENONE(16819-79-7)

Safety Data

• Hazardous Substances Data: 16819-79-7(Hazardous Substances Data)

Usage

General Description

2'-Ethylpropiophenone is a chemical compound with the molecular formula C11H14O. It is a yellowish liquid with a sweet, floral odor and is commonly used as a fragrance ingredient in perfumes and cosmetics. 2'-Ethylpropiophenone is also utilized in the production of pharmaceuticals and as a flavoring agent in food products. It is considered to be a mild skin and eye irritant and should be handled with caution. Additionally,

Upstream product

• 1973-22-4 1-bromo-2-ethylbenzene 
• 67541-89-3 1-(2-ethylphenyl)propanol 
• 609-65-4 o-chlorobenzoyl chloride 
• 108-86-1 bromobenzene 
• 462-06-6 fluorobenzene 
• 96-22-0 pentan-3-one 

Downstream Products

• 56839-43-1 eperisone hydrochloride 
• 1126518-91-9 2-bromo-1-(2-ethylphenyl)propan-1-one 
• 67541-89-3 1-(2-ethylphenyl)propanol 

Relevant articles and documents

Preparation method of Eperisone hydrochloride impurity F

The invention provides a preparation method of Eperisone hydrochloride impurity F, which comprises the following steps: 2-bromoethylbenzene is used as a raw material, 1- (2-ethylphenyl) propanol is obtained through Grignard reaction, 2-ethyl propiophenone is obtained through oxidation reaction, and finally the Eperisone hydrochloride impurity F is obtained through Mannich reaction of the 2-ethyl propiophenone, paraformaldehyde and piperidine hydrochloride by a one-pot method. The structure of the Eperisone hydrochloride impurity F is shown as a formula (I), the purity of theEperisone hydrochloride impurity F obtained by adopting the technical scheme provided by the invention can reach 99%, and the Eperisone hydrochloride impurity F can be used as a reference substance for experimental research.

Regioselectivity of the Base-Induced Ring Cleavage of 1-Oxygenated Derivatives of Cyclobutabenzene

Oxy anions 3 generated from 1,2-dihydrocyclobutabenzen-1-ones 1 through addition of a charged nucleophile or from 1-hydroxy-1,2-dihydrocyclobutabenzenes 2 by deprotonation with base lead to stable products through distal and/or proximal cleavage of the strained four-membered ring via benzyl carbanion 4 and/or aryl carbanion 5. A systematic study of this process reveals the relative stability of the two isomeric carbanions 4 and 5 as a key factor in determining the course of the ring-cleavage reaction. While benzyl carbanions 4 can be trapped with carbon electrophiles, attempts at trapping aryl carbanions 5 with electrophiles other than H+ failed. In protic solvents, the magnesium salt of the tertiary alcohol 2 shows an increased rate of proximal cleavage as compared to its alkali salts. From this, we conclude that, in contrast to benzyl carbanions 4, free aryl carbanions 5 are of transient existence only. Proximal C,C-bond cleavage seems to occur either through protonation of 5 from a fast, reversible equilibrium 3?5 in which 3 strongly predominates, or in protic solvents possibly even through a rate-limiting protonation of 3 at the aromatic C-atom, bypassing free anion 5 altogether. Thus, additional factors other than just the relative stability of isomeric carbanions 4 and 5 are of importance in determining the regiochemistry of the base-induced C,C-bond cleavage in ketones 1 and in alcohols 2.