168263-75-0Relevant articles and documents
Charge neutral rhenium tricarbonyl complexes of tridentate N-heterocyclic carbene ligands that bind to amyloid plaques of Alzheimer's disease
Barnard, Peter J.,Donnelly, Paul S.,McLean, Catriona A.,Noor, Asif,Wiratpruk, Nuchareenat
, p. 4559 - 4569 (2020/04/17)
Two tridentate ligand systems bearing N-heterocyclic carbene (NHC), amine and carboxylate donor groups coupled to benzothiazole- or stilbene-based amyloid binding moieties were synthesised. Reaction of the imidazolium salt containing pro-ligands with Re(CO)5Cl yielded the corresponding rhenium metal complexes which were characterised by NMR, and X-ray crystallography. These ligands are of interest for the potential preparation of technetium-99m imaging agents for Alzheimer's disease and the capacity of these rhenium complexes bind to amyloid fibrils composed of amyloid-β peptide and amyloid plaques in human frontal cortex brain tissue was evaluated using fluorescence microscopy. These studies show that the complexes bound efficiently to amyloid-β fibrils and some evidence of binding to amyloid-β plaques.
Stable Europium(III) Complexes with Short Linkers for Site-Specific Labeling of Biomolecules
Faschinger, Felix,Ertl, Martin,Zimmermann, Mirjam,Horner, Andreas,Himmelsbach, Markus,Sch?fberger, Wolfgang,Kn?r, Günther,Gruber, Hermann J.
, p. 721 - 732 (2017/12/12)
In this study, two new terpyridine-based EuIII complexes were synthesized, the structures of which were optimized for luminescence resonance energy-transfer (LRET) experiments. The complexes showed high quantum yields (32 %); a single long life
Ring expansion of 2-(1-Hydroxyalkyl)azetidines to 4-(2-Chloroethyl) oxazolidinones
Couty, Francois,Drouillat, Bruno,Lemee, Frederic
experimental part, p. 794 - 801 (2011/03/22)
2-(1-Hydroxyalkyl)azetidines react with bis(trichloromethyl) carbonate (BTC) after basic treatment to afford 4-(2-chloroethyl)oxazolidinones. The scope of this rearrangement was examined in detail and its efficiency was shown to depend on the class of the