16832-24-9

Basic information

• Product Name: H-HIS(BZL)-OH
• Synonyms: (S)-2-AMINO-3-(1-BENZYL-1H-IMIDAZOL-4-YL)PROPANOIC ACID;N-IM-BENZYL-L-HISTIDINE;IM-BENZYL-L-HISTIDINE;H-HIS(BZL)-OH;HISTIDINE(BZL)-OH;1-Benzyl-L-histidine;NSC 231954;L-Histidine, 1-(phenylMethyl)-
• CAS NO: 16832-24-9
• Molecular Formula: C₁₃H₁₅N₃O₂
• Molecular Weight: 245.28
• Mol File: 16832-24-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 248-249℃
• Boiling Point: 484.8 °C at 760 mmHg
• Flash Point: 247 °C
• Appearance: /
• Density: 1.27
• Vapor Pressure: 3.29E-10mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: Store at RT.
• CAS DataBase Reference: H-HIS(BZL)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-HIS(BZL)-OH(16832-24-9)
• EPA Substance Registry System: H-HIS(BZL)-OH(16832-24-9)

Safety Data

• Safety Statements: 36/37
• WGK Germany: 3
• Hazardous Substances Data: 16832-24-9(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C13H15N3O2/c14-12(13(17)18)6-11-8-16(9-15-11)7-10-4-2-1-3-5-10/h1-5,8-9,12H,6-7,14H2,(H,17,18)/t12-/m1/s1

Upstream product

• 100-44-7 benzyl chloride 
• 71-00-1 L-histidine 
• 20898-44-6 Boc-His(Bzl)-OH 
• 71-00-1 L-histidine 

Downstream Products

• 19817-75-5 N'-benzyl-L-histidine methyl ester 
• 114787-96-1 1-Benzyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid 
• 133868-67-4 1-benzyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid methyl ester 
• 1300034-13-2 1-benzyl-1H-imidazo[4,5-c]pyridin-6-carboxylic acid methyl ester 
• 24886-03-1 Nα-Methyl-L-histidine 
• 122766-72-7 1-benzyl-N^α-(1-benzyl-N^α-benzyloxycarbonyl-L-histidyl)-L-histidine-benzyl ester 
• 122411-85-2 1benzyl-N^α-(N-benzyloxycarbonyl-L-phenylalanyl)-L-histidine-hydrazide 
• 120548-57-4 N-(1-benzyl-N^α-benzyloxycarbonyl-L-histidyl)-glycine-benzyl ester 
• 105374-43-4 N-(1-benzyl-N^α-benzyloxycarbonyl-L-histidyl)-glycine 
• 104882-34-0 1-benzyl-N^α-methyl-N^α-(toluene-4-sulfonyl)-L-histidine 
• 98189-03-8 N,N-dihexadecyl-N^α_his-α_ala-(t-butoxycarbonyl)-L-alanyl>-N^im-benzyl-L-histidinamide 
• 98189-06-1 N,N-dihexadecyl-N^α_his-Α_ala-(6-bromohexanoyl)-L-alanyl>-N^im-benzyl-L-histidinamide 
• 98189-02-7 N,N-dihexadecyl-N^α-(t-butoxycarbonyl)-N^im-benzyl-L-histidinamide 

Relevant articles and documents

PROCESS FOR SYNTHESIZING ERGOTHIONEINE AND RELATED COMPOUNDS

The invention provides a process for synthesising a compound of formula (V) wherein: formula (z) or a physiologically acceptable salt, tautomer, stereoisomer or mixture of stereoisomers thereof. The process utilizes a /V-benzyl protected histidine rather

Regiospecific alkylation of histidine and histamine at N-1 (τ)

Series of 1-alkyl histidines and histamines have been synthesized by the alkylation of the corresponding 5,6,7,8-tetrahydro-5-oxomidazo[1,5-c]pyrimidines with alkyl halides in aprotic solvents. The method of conversion of the intermediate quaternary salt to the amino acid or amino depends on the nature of the alkyl group.

CYCLIC CARBAMATE ANALOGUES OF (+)-PILOCARPINE

Pilocarpine analogues are provided having the structure STR1 where one of R 1 or R 2 is an alkyl, such as methyl, ethyl, propyl, butyl, and so forth, and the corresponding secondary alkyl groups, an aralkyl, such as benzyl, phenylethyl, phenylpropyl, and the corresponding secondary aralkyl residues, or a cycloalkyl having less than about 12 carbon atoms. R 3 has at least two carbon atoms but less than about 9. These pilocarpine analogues have improved duration of biological activity with respect to pilocarpine. A particularly preferred compound is a muscarinic agonist equipotent with pilocarpine, where R 2 is methyl, and R 3 is ethyl.