1684-40-8 Usage
Description
Tacrine Hydrochloride, also known as 1,2,3,4-tetrahydro-9-aminoacridine hydrochloride (THA, Cognex), is a reversible cholinesterase inhibitor that has been used in the treatment of Alzheimer's disease. It is a pale yellow solid with a bitter taste and is the first therapeutic launched specifically for Alzheimer's disease treatment. Tacrine functions as an inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase, and it also inhibits the uptake of serotonin and norepinephrine in rat cerebral cortex. It is used to increase the levels of acetylcholine in patients with Alzheimer's disease, based on observations of reduced concentrations of ChAT and AChE in the brain.
Uses
Used in Pharmaceutical Industry:
Tacrine Hydrochloride is used as an anticholinesterase for the therapy of memory deficits in patients with Alzheimer's disease. It acts as a cognitive adjuvant by elevating the acetylcholine level in the cerebral cortex and slowing the degradation of acetylcholine from intact cholinergic neurons. Additionally, it selectively blocks potassium channels in the central nervous system, resulting in an increased release of acetylcholine and a prolongation of the action potential of the presynaptic cholinergic neurons.
Used in Alzheimer's Disease Treatment:
Tacrine Hydrochloride is used as a potent centrally acting anticholinesterase for the treatment of Alzheimer's disease. It has demonstrated clinically significant improvement in cognition in patients with the disease. Although the underlying cause of the dementing process is not altered, the beneficial effects of tacrine may be due to its multiple effects on several neurotransmitter systems.
Brand Name:
Cognex (Sciele) is the brand name for Tacrine Hydrochloride.
Originator
NIH (U.S.A.)
Air & Water Reactions
Water soluble.
Reactivity Profile
TACRINE HYDROCHLORIDE is incompatible with strong oxidizing agents, acid chlorides and acid anhydrides . Neutralize bases in slightly exothermic reactions.
Fire Hazard
Flash point data for TACRINE HYDROCHLORIDE are not available; however, TACRINE HYDROCHLORIDE is probably combustible.
Biological Activity
Potent cholinesterase inhibitor, a cognition enhancer in vivo .
Metabolism
Tacrine is
extensively metabolized by CYP450 to at least three metabolites. The major metabolite, 1-hydroxy-tacrine, is active. Its elimination half-life is
between 1.5 and 4 hours, with metabolites being are excreted via the urine.
Check Digit Verification of cas no
The CAS Registry Mumber 1684-40-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,8 and 4 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1684-40:
(6*1)+(5*6)+(4*8)+(3*4)+(2*4)+(1*0)=88
88 % 10 = 8
So 1684-40-8 is a valid CAS Registry Number.
InChI:InChI=1/C13H14N2.ClH/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13;/h1,3,5,7H,2,4,6,8H2,(H2,14,15);1H
