168618-46-0 Usage
Description
3-(6-(Methoxycarbonyl)naphthalen-2-yl)benzoic acid is a complex organic compound characterized by its unique chemical structure, which features a naphthalene ring connected to a benzoic acid group through a carbonyl bridge. This molecule is known for its potential applications in various fields due to its specific chemical properties.
Uses
Used in Pharmaceutical Industry:
3-(6-(Methoxycarbonyl)naphthalen-2-yl)benzoic acid is used as a reagent for the synthesis of benzamide derivatives, which serve as human sirtuin 2 (SIRT2) inhibitors. These inhibitors have demonstrated anti-proliferative effects on cancer cells, making them a valuable tool in the development of novel cancer treatments.
In the synthesis process, 3-(6-(Methoxycarbonyl)naphthalen-2-yl)benzoic acid plays a crucial role in the formation of the final benzamide product, which can modulate the activity of SIRT2, a protein involved in various cellular processes, including cell survival, genome stability, and aging. By inhibiting SIRT2, these benzamide derivatives can potentially disrupt cancer cell growth and proliferation, offering a new avenue for cancer therapy.
Check Digit Verification of cas no
The CAS Registry Mumber 168618-46-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,8,6,1 and 8 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 168618-46:
(8*1)+(7*6)+(6*8)+(5*6)+(4*1)+(3*8)+(2*4)+(1*6)=170
170 % 10 = 0
So 168618-46-0 is a valid CAS Registry Number.
168618-46-0Relevant articles and documents
Convenient Preparation of 11H-Benzofluorenone and 11H-Benzofluorenone
Streitweiser, Andrew,Brown, Sandra M.
, p. 904 - 906 (1988)
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Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton
Sakai, Taki,Matsumoto, Yotaro,Ishikawa, Minoru,Sugita, Kazuyuki,Hashimoto, Yuichi,Wakai, Nobuhiko,Kitao, Akio,Morishita, Era,Toyoshima, Chikashi,Hayashi, Tomoatsu,Akiyama, Tetsu
, p. 328 - 339 (2015/03/03)
Human sirtuin 2 (SIRT2) is an attractive target molecule for development of drugs to treat neurodegenerative diseases and cancer, because SIRT2 inhibitors have a protective effect against neurodegeneration and an anti-proliferative effect on cancer stem c
UII-MODULATING COMPOUNDS AND THEIR USE
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Page/Page column 42-43, (2008/12/05)
Disclosed herein are novel aromatic-containing compounds and methods for using various aromatic-containing compounds for treatment and prevention of diseases and disorders related to the Urotensin II receptor.
