168618-47-1 Usage
Description
2'-METHOXY-BIPHENYL-3-CARBOXYLIC ACID, also known as 2'-Methoxy[1,1''-biphenyl]-3-carboxylic Acid, is an organic compound with the molecular formula C13H10O3. It is a white crystalline solid that serves as a crucial intermediate in various chemical reactions and processes. Its structure features a biphenyl core with a methoxy group at the 2' position and a carboxylic acid group at the 3 position, which contributes to its reactivity and versatility in chemical synthesis.
Uses
Used in Chemical Synthesis:
2'-METHOXY-BIPHENYL-3-CARBOXYLIC ACID is used as a chemical intermediate for the synthesis of various compounds, particularly in the pharmaceutical and agrochemical industries. Its unique structure allows for further functionalization and modification, making it a valuable building block for the development of new molecules with potential applications in these fields.
Used in Suzuki-Miyaura Coupling:
In the field of organic chemistry, 2'-METHOXY-BIPHENYL-3-CARBOXYLIC ACID is used as a useful intermediate in the ligandless Suzuki-Miyaura coupling of aryl halides with arylboronic acids in water. This reaction is a powerful method for the formation of carbon-carbon bonds, which are essential in the synthesis of complex organic molecules, including those with biological activity.
The Suzuki-Miyaura coupling is a widely used cross-coupling reaction in organic chemistry, allowing for the formation of biaryl compounds from aryl halides and arylboronic acids. The use of 2'-METHOXY-BIPHENYL-3-CARBOXYLIC ACID as an intermediate in this reaction enables the synthesis of a wide range of biaryl compounds with potential applications in various industries, such as pharmaceuticals, materials science, and agrochemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 168618-47-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,8,6,1 and 8 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 168618-47:
(8*1)+(7*6)+(6*8)+(5*6)+(4*1)+(3*8)+(2*4)+(1*7)=171
171 % 10 = 1
So 168618-47-1 is a valid CAS Registry Number.
168618-47-1Relevant articles and documents
A general palladium-catalyzed cross-coupling of aryl fluorides and organotitanium (IV) reagents
He, Xiao-Yun
, p. 823 - 832 (2021/07/19)
Pd(OAc)2/1-[2-(di-tert-butylphosphanyl)phenyl]-4-methoxy-piperidine was demonstrated to effectively catalyze cross-coupling of aryl fluoride and aryl(alkyl) titanium reagent. Both electron-deficient and electron-rich aryl fluoride can react effectively with nucleophile and provide extensive functional groups tolerance. 2-Arylated product was realized by selective activation of the C–F bond. Graphic abstract: [Figure not available: see fulltext.].
The 1,3-diaminobenzene-derived aminophosphine palladium pincer complex {C6H3[NHP(piperidinyl)2]2Pd(Cl)} - A highly active Suzuki-Miyaura catalyst with excellent functional group tolerance
Bolliger, Jeanne L.,Frech, Christian M.
experimental part, p. 1075 - 1080 (2010/06/17)
The rapidly prepared 1,3-diaminobenzenederived aminophosphine pincer complex {C6H3 [NHP(piperidinyl)2] 2Pd(Cl)} (1) is an effective Suzuki catalyst with excellent functional group tolerance. Side-product formations, such as homocoupling, debromation or protodeboration have only rarely been detected and if so, were in all cases below the 5% level. The presented reaction protocol is universally applicable. Experimental observations indicate that palladium nanoparticles are the catalytically active form of 1.
