168699-41-0

Basic information

• Product Name: methyl 4-[(1E)-(hydroxyimino)methyl]benzoate
• Synonyms: methyl 4-[(1E)-(hydroxyimino)methyl]benzoate
• CAS NO: 168699-41-0
• Molecular Weight: 179.175
• Mol File: 168699-41-0.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: methyl 4-[(1E)-(hydroxyimino)methyl]benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-[(1E)-(hydroxyimino)methyl]benzoate(168699-41-0)
• EPA Substance Registry System: methyl 4-[(1E)-(hydroxyimino)methyl]benzoate(168699-41-0)

Safety Data

• Hazardous Substances Data: 168699-41-0(Hazardous Substances Data)

Upstream product

• 99-75-2 4-methyl-benzoic acid methyl ester 
• 874-60-2 4-methyl-benzoyl chloride 
• 1571-08-0 methyl 4-formylbenzoate 

Downstream Products

• 1129-35-7 4-cyanobenzoic acid methyl ester 
• 196301-94-7 methyl 4-(5-methyl-1,2,4-oxadiazol-3-yl)benzoate 
• 856251-61-1 4-[4-(4-tert-butylbenzoyl)-5-(4-cyclohexylphenyl)-4,5-dihydroisoxazol-3-yl]benzoic acid methyl ester 
• 856251-58-6 4-[5-(4-tert-butylbenzoyl)-4-(4-cyclohexylphenyl)-4,5-dihydroisoxazol-3-yl]benzoic acid methyl ester 
• 82544-82-9 methyl 4-(1H-tetrazole-5-yl)benzoate 
• 101023-70-5 4-methoxycarbonylbenzhydroxamic acid chloride 
• 72331-27-2 4-oxycyano-benzoic acid methyl ester 
• 1350759-88-4 tert-butyl 3-[4-(methoxycarbonyl)phenyl]-1-oxa-2,8-diazaspiro[4,5]dec-2-ene-8-carboxylate 

Relevant articles and documents

Visible-Light-Promoted Metal-Free Synthesis of (Hetero)Aromatic Nitriles from C(sp3)?H Bonds**

The metal-free activation of C(sp3)?H bonds to value-added products is of paramount importance in organic synthesis. We report the use of the commercially available organic dye 2,4,6-triphenylpyrylium tetrafluoroborate (TPP) for the conversion of methylarenes to the corresponding aryl nitriles via a photocatalytic process. Applying this methodology, a variety of cyanobenzenes have been synthesized in good to excellent yield under metal- and cyanide-free conditions. We demonstrate the scope of the method with over 50 examples including late-stage functionalization of drug molecules (celecoxib) and complex structures such as l-menthol, amino acids, and cholesterol derivatives. Furthermore, the presented synthetic protocol is applicable for gram-scale reactions. In addition to methylarenes, selected examples for the cyanation of aldehydes, alcohols and oximes are demonstrated as well. Detailed mechanistic investigations have been carried out using time-resolved luminescence quenching studies, control experiments, and NMR spectroscopy as well as kinetic studies, all supporting the proposed catalytic cycle.

MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

An efficient catalytic method for the Beckmann rearrangement of ketoximes to amides and aldoximes to nitriles mediated by propylphosphonic anhydride (T3P)

An efficient method for the Beckmann rearrangement of ketoximes to amides mediated by a catalytic amount (15 mol %) of propylphosphonic anhydride (T3P) is described. Aldoximes underwent second order Beckmann rearrangement to provide the corresponding nitriles in excellent yields on reacting with T3P (15 mol %) at room temperature. The main advantages of this environmentally friendly protocol include procedural simplicity, and particularly ease of isolation of the products.