168786-98-9

Basic information

• Product Name: METHYL-2,3-DIDEOXY-3-FLUORO-5-O-(4-phenylbenzoyl)-ALPHA-D-ERYTHRO-PENTOFURANOSIDE
• Synonyms: METHYL-2,3-DIDEOXY-3-FLUORO-5-O-(4-phenylbenzoyl)-ALPHA-D-ERYTHRO-PENTOFURANOSIDE;Methyl-2,3-Dideoxy--Fluoro-5-O-(4-phenylbenzoyl)-Alpha-D-erythro-pentofuranoside;METHYL-2,3-DIDEOXY-3-FLUORO-5-O-(4-phenylbenzoyl)-ALPHA-D-ERYTHRO-;Methyl 2,3-dideoxy-3-fluoro-alpha-D-erythro-pentofuranoside 5-[1,1'-biphenyl]-4-carboxylate
• CAS NO: 168786-98-9
• Molecular Formula: C19H19FO4
• Molecular Weight: 330.3501632
• EINECS: -0
• Mol File: 168786-98-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.23±0.1 g/cm3 (20 oC 760 Torr), Calc.*
• CAS DataBase Reference: METHYL-2,3-DIDEOXY-3-FLUORO-5-O-(4-phenylbenzoyl)-ALPHA-D-ERYTHRO-PENTOFURANOSIDE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL-2,3-DIDEOXY-3-FLUORO-5-O-(4-phenylbenzoyl)-ALPHA-D-ERYTHRO-PENTOFURANOSIDE(168786-98-9)
• EPA Substance Registry System: METHYL-2,3-DIDEOXY-3-FLUORO-5-O-(4-phenylbenzoyl)-ALPHA-D-ERYTHRO-PENTOFURANOSIDE(168786-98-9)

Safety Data

• Hazardous Substances Data: 168786-98-9(Hazardous Substances Data)

Usage

General Description

METHYL-2,3-DIDEOXY-3-FLUORO-5-O-(4-phenylbenzoyl)-ALPHA-D-ERYTHRO-PENTOFURANOSIDE is a chemical compound that belongs to the class of nucleosides. It is a derivative of deoxyribose, a type of sugar found in DNA. The compound contains a fluorine atom and a phenylbenzoyl group, which are both important for its function and properties. This chemical has potential applications in the field of pharmaceuticals and medicine, particularly in the development of antiviral and anticancer drugs, as it can potentially inhibit various biological processes and pathways through interactions with nucleic acids and enzymes. It is important to handle this compound with care and attention due to its potential biological and pharmacological activity.

Upstream product

• 129468-49-1 Methyl 2-deoxy-5-O-(4-phenylbenzoyl)-β-D-threo-pentofuranoside 
• 125611-95-2 methyl 2-deoxy-5-O-(4-phenylbenzoyl)-β-D-erythro-pentofuranoside 
• 125611-99-6 methyl 2,3-dideoxy-5-O-(4-phenylbenzoyl)-β-D-glycero-pentofuranoside*0.25H2O 
• 129468-48-0 Methyl 2-deoxy-5-O-(4-phenylbenzoyl)-β-D-glyceropentofuranosid-3-ulose 
• 125611-96-3 Methyl 2-Deoxy-3-O-(methylsulfonyl)-5-O-(4-phenylbenzoyl)-α-D-erythro-pentofuranoside 

Downstream Products

• 168787-13-1 (E)-1-<2,3-dideoxy-3-fluoro-5-O-(4-phenylbenzoyl)-D-erythro-pentofuranosyl>-5-ethylidene-hydantoin 

Relevant articles and documents

A new approach for syntheses of 2′,3′-dideoxy-2′,3′ -dehydronucleosides using 2,2-difluoro-1,3-dimethylimidazolidine (DFI) as a dehydrating reagent

We found that 2,2-difluoro-1,3-dimethylimidazolidine (DFI) is useful for not only fluorination but also dehydrating reactions. This dehydrating ability of DFI was applied to the syntheses of dihydrofurans (2) that are possible starting materials for various anticancer or antiviral drugs.

Synthesis and Antivirial Evaluation of Quinazoline, Thieno/pyrimidine, and Lumazine Analogues of 3'-Fluoro-3'-deoxythymidine (FLT)

2,4(1H,3H)-Quinazolinediones 3a-c, lumazine (3d) and thienopyrimidine-2,4(1H,3H)-dione (8) were silylated and condensed with methyl 2,3-dideoxy-3-fluoro-5-O-(4-phenylbenzoyl)-β-D-erythro-pentafuranoside (2) by using trimethylsilyl triflate as a catalyst to afford the corresponding cyclic nucleosides 4 and 9 and acyclic nucleosides 5 and 10.Removal of the protecting group from the glycon moiety was achieved in good yields by treatment with sodium methoxide in methanol at room temperature.The new FLT analogues were devoid of activity against HIV-1 and HSV-1. - Keywords: Nucleosides / HIV / 3'-Fluoronucleosides / FLT analogues