168835-91-4

Basic information

• Product Name: N-(4-IODOPHENYL)-6,7-DIMETHOXY-4-QUINAZOLINAMINE
• Synonyms: N-(4-IODOPHENYL)-6,7-DIMETHOXY-4-QUINAZOLINAMINE;N-(6,7-DIMETHOXY-4-QUINAZOLINYL)-N-(4-IODOPHENYL)AMINE;N-(4-iodophenyl)-6,7-dimethoxyquinazolin-4-amine
• CAS NO: 168835-91-4
• Molecular Formula: C₁₆H₁₄IN₃O₂
• Molecular Weight: 407.21
• Mol File: 168835-91-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 489.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.654±0.06 g/cm3(Predicted)
• PKA: 5.54±0.30(Predicted)
• CAS DataBase Reference: N-(4-IODOPHENYL)-6,7-DIMETHOXY-4-QUINAZOLINAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-IODOPHENYL)-6,7-DIMETHOXY-4-QUINAZOLINAMINE(168835-91-4)
• EPA Substance Registry System: N-(4-IODOPHENYL)-6,7-DIMETHOXY-4-QUINAZOLINAMINE(168835-91-4)

Safety Data

• Hazardous Substances Data: 168835-91-4(Hazardous Substances Data)

Upstream product

• 26759-46-6 methyl 2-amino-4,5-dimethoxybenzoate 
• 13794-72-4 6,7-dimethoxy quinazolin-4-one 
• 13790-39-1 6,7-dimethoxy-4-chloroquinazoline 
• 540-37-4 p-aminoiodobenzene 

Downstream Products

• 882511-60-6 [4-(3-dicyclohexylamino-prop-1-ynyl)-phenyl]-(6,7-dimethoxy-quinazolin-4-yl)-amine 

Relevant articles and documents

Quinazoline compounds and pharmaceutical compositions containing them

The use of a compound of formula (I) or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2, NH or NR8 where R8 is hydrogen or C1-6alkyl; Ra is a 3-quinoline group or a group of sub-formula (i) where R5, R6 and R7 are various specific organic groups, in the preparation of a medicament for use in the inhibtion of aurora 2 kinase. Novel compounds of formula (I) and pharmaceutical compositions useful in the treatment of cancer are also described and claimed.

QUINAZOLINE DERIVATIVES

A compound of formula (I) or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2 or NR10 where R10 is hydrogen or C1-6 alkyl, and R1, R2, R3, R4, R5, R6, R7, R8 and R9 are various specified organic groups. These compounds are inhibitors of aurora 2 kinase, and are useful in the treatment of cancer.