168918-48-7

Basic information

• Product Name: [2-((E)-2-Diisopropylcarbamoyl-vinyl)-phenoxy]-acetic acid ethyl ester
• Synonyms: [2-((E)-2-Diisopropylcarbamoyl-vinyl)-phenoxy]-acetic acid ethyl ester
• CAS NO: 168918-48-7
• Molecular Weight: 333.428
• Mol File: 168918-48-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [2-((E)-2-Diisopropylcarbamoyl-vinyl)-phenoxy]-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [2-((E)-2-Diisopropylcarbamoyl-vinyl)-phenoxy]-acetic acid ethyl ester(168918-48-7)
• EPA Substance Registry System: [2-((E)-2-Diisopropylcarbamoyl-vinyl)-phenoxy]-acetic acid ethyl ester(168918-48-7)

Safety Data

• Hazardous Substances Data: 168918-48-7(Hazardous Substances Data)

Upstream product

• 41873-61-4 ethyl (2-formylphenoxy)acetate 

Relevant articles and documents

Synthesis and biochemical evaluation of (carbamoylalkenyl)phenyloxy carboxylic acid derivatives as non-steroidal 5α-reductase inhibitors

Several (carbamoylalkenyl)- and (carbamoylalkenyl)phenyloxy carboxylic acids and some of their ethyl esters were synthesized and evaluated in vitro as inhibitors of steroid 5α-reductase. Inhibitors of this enzyme may be useful in treating dihydrotestosterone-related diseases such as prostate cancer and benign prostatic hyperplasia. Using an enzyme preparation obtained from human prostate carcinoma tissue, the inhibition values ranged from 0 to 57% at the given dose of 100 μM. In the series of free acids, surprisingly, the compounds showed only modest inhibitory potency (0-26%). By contrast, the ethyl esters displayed inhibition values up to 57%. Sttructure-activity relationships are discussed.