16899-18-6

Basic information

• Product Name: L-2-AMinothiazoline-4-carboxylic Acid
• Synonyms: L-2-AMinothiazoline-4-carboxylic Acid;(4R)-2-AMino-4,5-dihydro-4-thiazolecarboxylic Acid;(R)-2-AMino-4,5-dihydro-4-thiazolecarboxylic Acid;L-2-IMino-4-thiazolidinecarboxylic Acid;L-2-amino-Delta(2)-thiazoline-4-carboxylic acid
• CAS NO: 16899-18-6
• Molecular Formula: C₄H₆N₂O₂S
• Molecular Weight: 146
• Product Categories: Amines;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Amines, Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
• Mol File: 16899-18-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 221 °C
• Boiling Point: 405.9±55.0 °C(Predicted)
• Appearance: /
• Density: 1.85±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly, Heated), Water (Slightly)
• PKA: 2.31±0.20(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: L-2-AMinothiazoline-4-carboxylic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: L-2-AMinothiazoline-4-carboxylic Acid(16899-18-6)
• EPA Substance Registry System: L-2-AMinothiazoline-4-carboxylic Acid(16899-18-6)

Safety Data

• Hazardous Substances Data: 16899-18-6(Hazardous Substances Data)

Usage

Description

L-2-AMinothiazoline-4-carboxylic Acid, a thiozole derivative, is a compound with the R configuration. It plays a crucial role in the conversion to L-cysteine by the enzyme 2-amino-Δ2-thiazoline-4-carboxylic acid hydrolase (ATCase) in certain bacteria upon induction by S-compounds.

Uses

Used in Pharmaceutical Industry:
L-2-AMinothiazoline-4-carboxylic Acid is used as an intermediate in the synthesis of various pharmaceutical compounds for its ability to be converted to L-cysteine, which is an essential amino acid involved in various biological processes.
Used in Biochemical Research:
L-2-AMinothiazoline-4-carboxylic Acid is used as a research tool in the study of enzyme mechanisms and the role of L-cysteine in cellular processes, particularly in the context of bacterial metabolism and the action of ATCase.
Used in Bacterial Metabolism Studies:
L-2-AMinothiazoline-4-carboxylic Acid is used as a substrate in the investigation of the enzyme 2-amino-Δ2-thiazoline-4-carboxylic acid hydrolase (ATCase) and its role in the conversion of this compound to L-cysteine in certain bacteria, providing insights into bacterial metabolism and potential targets for antibiotic development.

Upstream product

• 56-89-3 L-cystine 
• 151-50-8 potassium cyanide 
• 52-90-4 L-Cysteine 
• 44521-10-0 L-cysteine sodium salt 
• 143-33-9 sodium cyanide 
• 420-04-2 CYANAMID 
• 52-89-1 l-cysteine hydrochloride 

Relevant articles and documents

Methods Of Stapling And Unstapling Peptides And Proteins

The present disclosure pertains to the field peptide stapling and/or macrocyclization, where a structural motif is used to improve the properties of amino acid sequences (e.g. protease resistance, cellular penetration, biological activity). Also within th

The structure of itca , a urinary metabolite of cyanide

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