169032-17-1

Basic information

• Product Name: 2-[4-(4-chloro-butyryl)-phenyl]-2-methyl-propionitrile
• Synonyms: 2-[4-(4-chloro-butyryl)-phenyl]-2-methyl-propionitrile
• CAS NO: 169032-17-1
• Molecular Weight: 249.74
• Mol File: 169032-17-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-[4-(4-chloro-butyryl)-phenyl]-2-methyl-propionitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(4-chloro-butyryl)-phenyl]-2-methyl-propionitrile(169032-17-1)
• EPA Substance Registry System: 2-[4-(4-chloro-butyryl)-phenyl]-2-methyl-propionitrile(169032-17-1)

Safety Data

• Hazardous Substances Data: 169032-17-1(Hazardous Substances Data)

Upstream product

• 169280-04-0 1-[4-(1-Bromo-1-methyl-ethyl)-phenyl]-4-chloro-butan-1-one 
• 7677-24-9 trimethylsilyl cyanide 
• 1195-98-8 2-methyl-2-phenylpropionitrile 
• 4635-59-0 4-Chlorobutanoyl chloride 
• 76469-88-0 methyl 4-(cyanomethyl)benzoate 
• 394222-37-8 2-(4-(4-hydroxybutanoyl)phenyl)-2-methylpropanenitrile 
• 1308679-43-7 C₁₅H₁₄NO₃^(1-)*Na⁽¹⁺⁾ 
• 129488-73-9 methyl 4-(1-cyano-1-methylethyl)-benzoate 
• 169032-12-6 2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyl acetate 
• 57625-74-8 methyl 2-methyl-2-phenylpropionate 
• 18755-52-7 (2-acetoxy-1,1-dimethylethyl)benzene 
• 2173-69-5 2-methyl-2-phenyl-propan-1-ol 
• 826-55-1 2-methyl-2-phenylpropionic acid 
• 101184-73-0 2-(4-bromophenyl)-2-methylpropanenitrile 

Downstream Products

• 169280-21-1 2-[4-(4-chloro-butyryl)-phenyl]-2-methyl-propionic acid 
• 169280-06-2 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionitrile 
• 394222-36-7 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanenitrile 
• 83799-24-0 fexofenadine 
• 154477-54-0 2-[4-(4-Chloro-butyryl)-phenyl]-2-methyl-propionic acid, methyl ester 
• 169032-23-9 (R)-(+)-2-[4-(1-Hydroxy-4-(4-hydroxydiphenylmethyl-1-piperidyl)butyl)phenyl]isobutyronitrile 
• 169032-21-7 (S)-(-)-2-[4-(1-Hydroxy-4-(4-hydroxydiphenylmethyl-1-piperidyl)butyl)phenyl]isobutyronitrile 
• 169032-20-6 (S)-(-)-2-[4-(1-Hydroxy-4-chlorobutyl)phenyl]isobutyronitrile 
• 169032-22-8 (R)-(+)-2-[4-(1-Hydroxy-4-chlorobutyl)phenyl]isobutyronitrile 

Relevant articles and documents

Process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile

A new process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl- propanenitrile is described. This compound can be used for the production of drugs, such as Fexofenadine.

Intermediates useful for the preparation of antihistaminic piperidine derivatives

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula whereinW represents —C(=O)— or —CH(OH)—;R1 represents hydrogen or hydroxy;R2 represents hydrogen;R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2;n is an integer of from 1 to 5;m is an integer 0 or 1;R3 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof,with the proviso that where R1 and R2 are taken together to form a second bond between the carbon atoms bearing R1 and R2 or where R1 represented hydroxy, m is an integer 0.

Antihistaminic compounds, process for their preparation and pharmaceutical compositions containing them

The present invention relates to terfenadine derivatives of formula where R?, which is in position 1 or 2 of the tetrazole ring, stands for H, or a linear or branched alkyl group containing from 1 to 6 carbon atoms; R? and R?, different from one another, are selected between H and OH, and their pharmaceutically acceptable salts.