16927-49-4

Basic information

• Product Name: 4-ANILINO-3-NITROBENZOIC ACID
• Synonyms: Benzoic acid,3-nitro-4-(phenylaMino)-
• CAS NO: 16927-49-4
• Molecular Formula: C₁₃H₁₀N₂O₄
• Molecular Weight: 258.24
• Mol File: 16927-49-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 445.7°C at 760 mmHg
• Flash Point: 223.4°C
• Appearance: /
• Vapor Pressure: 9.98E-09mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-ANILINO-3-NITROBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ANILINO-3-NITROBENZOIC ACID(16927-49-4)
• EPA Substance Registry System: 4-ANILINO-3-NITROBENZOIC ACID(16927-49-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 16927-49-4(Hazardous Substances Data)

Usage

General Description

4-ANILINO-3-NITROBENZOIC ACID is a chemical compound with the molecular formula C13H10N2O4. It is also known as ANB or NBP. It is often used as a reagent in chemical analysis and as an indicator in titrations. It is a yellow to orange crystalline powder that is sparingly soluble in water but soluble in organic solvents. 4-ANILINO-3-NITROBENZOIC ACID is a nitroaromatic compound that is commonly used in the synthesis of dyes, pharmaceuticals, and other organic compounds. It is also used in biochemical research as a pH indicator and in the development of fluorescent probes for studying enzyme activity.

InChI:InChI=1/C13H10N2O4/c16-13(17)9-6-7-11(12(8-9)15(18)19)14-10-4-2-1-3-5-10/h1-8,14H,(H,16,17)/p-1

Upstream product

• 6319-40-0 4-bromo-3-nitrobenzoic acid 
• 62-53-3 aniline 
• 528-45-0 3,4-dinitrobenzoic acid 
• 453-71-4 3-nitro-4-fluorobenzoic acid 
• 96-99-1 4-chloro-3-nitrobenzoate 
• 610-39-9 3,4-Dinitrotoluene 
• 74-11-3 para-chlorobenzoic acid 

Downstream Products

• 55296-17-8 3-amino-4-(phenylamino)benzoic acid 
• 148304-23-8 3-nitro-4-phenylaminobenzoic acid methyl ester 
• 1256966-57-0 5-(benzothiazol-2-yl)-2-(N,N-dimethylammo)methyl-1-phenylbenzimidazole 
• 1256968-08-7 1-phenyl-2-(phenylmethoxy)methylbenzimidazole-5-carboxylic acid 
• 1256966-56-9 5-(benzothiazol-2-yl)-2-hydroxymethyl-1-phenylbenzimidazole 
• 1256966-55-8 5-(benzothiazol-2-yl)-1-phenyl-2-(phenylmethoxy)methylbenzimidazole 
• 21720-24-1 2'-methyl-1'-phenyl-1H,1'H-[2,5']bi[benzoimidazolyl] 
• 56886-60-3 2-(2-methyl-1-phenyl-1H-benzoimidazol-5-yl)-benzooxazole 
• 56886-52-3 2-(2-methyl-1-phenyl-1H-benzoimidazol-5-yl)-benzothiazole 
• 92437-43-9 2-methyl-1-phenyl-1H-benzoimidazole-5-carboxylic acid 
• 534-85-0 N-phenyl-1,2-benzenediamine 
• 68765-57-1 ethyl 3-amino-4-(phenylamino)benzoate 
• 356099-06-4 1-phenyl-1H-benzotriazole-5-carboxylic acid 
• 148304-27-2 4-anilino-3-nitro-benzoylhydrazine 

Relevant articles and documents

Structural Modifications of Benzimidazoles via Multi-Step Synthesis and Their Impact on Sirtuin-Inhibitory Activity

Benzimidazole derivatives have been shown to possess sirtuin-inhibitory activity. In the continuous search for potent sirtuin inhibitors, systematic changes on the terminal benzene ring were performed on previously identified benzimidazole-based sirtuin i

AGENT FOR TREATMENT OR PREVENTION OF DISEASES ASSOCIATED WITH ACTIVITY OF NEUROTROPHIC FACTORS

A compound depicted by the formula below, or a pharmaceutically acceptable salt or solvate thereof. wherein, R1 represents (1) a C3-6 alkyl group,(2) a C1-6 alkyl group substituted with one or more substituent group(s) sel

3-Nitro-4-amino benzoic acids and 6-amino nicotinic acids are highly selective agonists of GPR109b

A series of 3-nitro-4-substituted-aminobenzoic acids were prepared and found to act as potent and highly selective agonists of the orphan human GPCR GPR109b, a low affinity receptor for niacin. No activity was observed at the closely homologous high affinity niacin receptor, GPR109a. A second series, comprising 6-amino-substituted nicotinic acids was, also prepared and several analogues showed comparable activity to the nitroaryl series.