169280-32-4

Basic information

• Product Name: 2-(4-{1-hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl}phenyl)-2-methyl-1-(pyrrolidin-1-yl)propan-1-one
• Synonyms: 2-(4-{1-hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl}phenyl)-2-methyl-1-(pyrrolidin-1-yl)propan-1-one
• CAS NO: 169280-32-4
• Molecular Weight: 554.773
• Mol File: 169280-32-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(4-{1-hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl}phenyl)-2-methyl-1-(pyrrolidin-1-yl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-{1-hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl}phenyl)-2-methyl-1-(pyrrolidin-1-yl)propan-1-one(169280-32-4)
• EPA Substance Registry System: 2-(4-{1-hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl}phenyl)-2-methyl-1-(pyrrolidin-1-yl)propan-1-one(169280-32-4)

Safety Data

• Hazardous Substances Data: 169280-32-4(Hazardous Substances Data)

Upstream product

• 115-46-8 C₁₈H₂₁NO 
• 169280-18-6 4-chloro-1-[4-(1,1-dimethyl-2-oxo-2-pyrrolidin-1-yl-ethyl)-phenyl]-butan-1-one 
• 32454-35-6 2-(4-bromophenyl)-2-methylpropionic acid 

Downstream Products

• 138452-21-8 fexofenadine hydrochloride 

Relevant articles and documents

Fexofenadine hydrochloride of synthetic method

The invention discloses a fexofenadine hydrochloride synthesizing method. The fexofenadine hydrochloride synthesizing method comprises the steps of taking 2-(4-bromophenyl)-2-methylpropionate (2) as a raw material, enabling the 2-(4-bromophenyl)-2-methylpropionate (2) to react with nafoxidine to protect a carboxyl, and then reacting with [gamma]-butyrolactone to generate a compound 6, enabling the compound 6 to react with paratoluensulfonyl chloride, condensing a product and a [alpha], [alpha]-diphenyl-4-(Hydroxymethyl)-piperidine, and finally obtaining a target compound 1 through reduction and deprotection. The raw materials selected by the way are cheap to obtain; furthermore, the synthesizing method is mild in reaction condition, convenient to operate and smaller in environmental pollution, therefore the fexofenadine hydrochloride synthesizing method is an industrial way with a better application prospect.