169287-77-8 Usage
Description
BOC-PNA-G(Z)-OH is a chemical compound that features a peptide nucleic acid (PNA) monomer with a BOC protecting group on the N-terminus, a guanine base (G), and a Z protecting group on the C-terminus. This PNA monomer is a synthetic nucleic acid mimic designed to bind to complementary DNA or RNA sequences with high affinity and specificity. The BOC protecting group temporarily blocks the reactive amine on the N-terminus, while the Z protecting group ensures stability at the C-terminus. BOC-PNA-G(Z)-OH is instrumental in nucleic acid research, diagnostics, and therapeutics, particularly for the development of antisense oligonucleotides and molecular probes for detecting specific DNA or RNA sequences.
Uses
Used in Nucleic Acid Research:
BOC-PNA-G(Z)-OH is used as a research tool for studying the interactions between PNA and nucleic acids, such as DNA and RNA, due to its high binding affinity and specificity.
Used in Diagnostics:
In the diagnostics industry, BOC-PNA-G(Z)-OH is used as a molecular probe for detecting specific DNA or RNA sequences, contributing to the development of sensitive and accurate diagnostic assays.
Used in Therapeutics:
BOC-PNA-G(Z)-OH is utilized as a building block in the development of antisense oligonucleotides, which have potential therapeutic applications in modulating gene expression and treating various diseases by targeting specific nucleic acid sequences.
Used in Drug Development:
In the pharmaceutical industry, BOC-PNA-G(Z)-OH is used as a component in the design of drugs that target specific genetic sequences, potentially leading to more targeted and effective treatments for a range of conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 169287-77-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,9,2,8 and 7 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 169287-77:
(8*1)+(7*6)+(6*9)+(5*2)+(4*8)+(3*7)+(2*7)+(1*7)=188
188 % 10 = 8
So 169287-77-8 is a valid CAS Registry Number.
169287-77-8Relevant articles and documents
A convergent strategy for the modification of peptide nucleic acids: Novel mismatch-specific PNA-hybridization probes
Seitz, Oliver,Bergmann, Frank,Heindl, Dieter
, p. 2203 - 2206 (1999)
Coupling of nonnatural nucleobases to the orthogonally protected backbone 1 on the solid phase provided access to novel peptide nucleic acid (PNA) conjugates 2, which are difficult to synthesize by standard routes. Hybridization probes containing the thia
