169315-44-0Relevant articles and documents
Highly Efficient Multiple-Labeling Probes for the Visualization of Enzyme Activities
Song, Heng,Li, Yuyao,Chen, Yefeng,Xue, Chenghong,Xie, Hexin
, p. 13994 - 14002 (2019)
Quinone methide (QM) as a latent trapping unit has been widely explored in activity-based self-immobilizing reagents. However, further application of this strategy has been largely hampered by the limited labeling efficiency to proteins. In this study, a
Facile synthesis of 1,2,3-triazole-fused indolo- and pyrrolo[1,4]diazepines, DNA-binding and evaluation of their anticancer activity
Gour, Jitendra,Gatadi, Srikanth,Pooladanda, Venkatesh,Ghouse, Shaik Mahammad,Malasala, Satyaveni,Madhavi,Godugu, Chandraiah,Nanduri, Srinivas
supporting information, (2019/10/05)
A facile synthetic strategy has been developed for the generation of structurally diverse N-fused heterocycles. The formation of fused 1,2,3-triazole indolo and pyrrolodiazepines proceeds through an initial Knoevenagel condensation followed by intramolecu
Tetrahydro-benzofuran -4 - oxime-based triazole drug, preparation method and application thereof
-
, (2018/05/16)
The invention relates to a tetrahydrobenzofuran-4-ketoximetriazole medicine. The medicine is a cis-isomeride of tetrahydrobenzofuran-4-ketoximetriazole medicine, and also comprises pharmaceutically acceptable salts and derivatives of the tetrahydrobenzofuran-4-ketoximetriazole medicine. A preparation method of the tetrahydrobenzofuran-4-ketoximetriazole medicine comprises the following steps: preparing 3,6,6-trimethyl-6,7-dihydrobenzofuran-4(5H)-one (intermediate 1) and nitrine (intermediate 2), carrying out a condensation reaction to convert the intermediate 1 into cis-oxime (intermediate 3), separating, purifying, alkylating to obtain propargyl oxime ether (intermediate 4), and carrying out a copper catalyzed cycloaddition reaction on the intermediate 4 and the nitrine (intermediate 2) to synthesize 1,2,3-triazole substituted furocyclohexanone oxime and a derivative thereof. The above compounds have dual curative effects of antiulcer and stomach cancer resistance, and can be used in stomach cancer treatment as alternative medicines.