169328-87-4

Basic information

• Product Name: Thiophene, 2-bromo-3,4-dimethyl-
• CAS NO: 169328-87-4
• Molecular Formula: C6H7BrS
• Molecular Weight: 191.092
• Mol File: 169328-87-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Thiophene, 2-bromo-3,4-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiophene, 2-bromo-3,4-dimethyl-(169328-87-4)
• EPA Substance Registry System: Thiophene, 2-bromo-3,4-dimethyl-(169328-87-4)

Safety Data

• Hazardous Substances Data: 169328-87-4(Hazardous Substances Data)

Usage

General Description

Thiophene, 2-bromo-3,4-dimethyl- is a chemical compound with the molecular formula C6H7BrS. It is a derivative of thiophene, which is a five-membered aromatic ring with one sulfur atom. The 2-bromo-3,4-dimethyl- substitution on the thiophene ring confers specific chemical properties to the compound. This chemical can be used in organic synthesis, as a building block for the production of pharmaceuticals, agrochemicals, and materials. It may also have potential applications in the field of medicine, such as in drug discovery and development. Additionally, it is important to handle this chemical with caution and in compliance with safety regulations, as it may pose health and environmental risks.

Upstream product

• 632-15-5 3,4-dimethylthiophene 
• 128-08-5 N-Bromosuccinimide 

Downstream Products

• 1795-04-6 2,3,4-trimethylthiophene 

Relevant articles and documents

In vivo phenotypic drug discovery: Applying a behavioral assay to the discovery and optimization of novel antipsychotic agents

Phenotypic drug discovery (PDD) is increasingly being recognized as a viable compliment to target-based drug discovery (TDD). By measuring functional changes, typically at a systems level, PDD can facilitate the identification of compounds having a desirable pharmacology. This capability is particularly important when studying CNS diseases where drug efficacy may require modulation of multiple targets in order to overcome a robust, adaptive biological system. Here, we report the application of a mouse-based high-dimensional behavioral assay to the discovery and optimization of a structurally and mechanistically novel antipsychotic. Lead optimization focused on optimizing complex behavioral features and no explicit effort was made to identify the target (or targets) involved.

Porphyrin compositions

Novel metal porphyrin compositions useful as organic phosphors are provided. The novel compositions are prepared from commercially available porphyrin-containing starting materials. In one instance a novel palladium-containing porphyrin composition having a number average molecular weight of greater than 12,000 grams per mole was prepared from 5,10,15,20-tetrakis(3′,5′-di(hydroxy)phenyl)-21H-23H-porphyrin by reaction first with palladium(II) acetylacetonate, followed by reaction with 2-bromo-2-methylpropionyl bromide, and subsequent group transfer reaction of the alpha-bromo ester groups with 9,9-dioctyl-2-vinylfluorene in the presence of CuBr as a radical initiator. The product polymer exhibited a number average molecular weight of 12,884 grams per mole, a weight average molecular weight of 14,338 grams per mole, and a robust red phosphorescent emission. Porphyrin containing copoylmers comprising structural units derived from 9,9-dioctyl-2-vinylfluorene and 9-anthracenylmethyl methacrylate were prepared in a similar fashion.

Side-chain Effects on the Fragmentation Behaviour of Alkylthiophenes

The processes leading to the fragment ions formed from alkylthiophene molecule ions by benzylic cleavage without and with transfer of one hydrogen from the side-chain to the ring and the influence of additional methyl groups on the relative importance of these two fragmentation reactions were investigated.