169545-27-1 Usage
Uses
IRL 2500 is a potent endothelin ETB selective antagonist.
Biological Activity
Potent endothelin receptor antagonist; shows some selectivity for ET B receptors (IC 50 values are 1.3 and 94 nM for ET B and ET A receptors respectively). Inhibits ET B receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 169545-27-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,9,5,4 and 5 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 169545-27:
(8*1)+(7*6)+(6*9)+(5*5)+(4*4)+(3*5)+(2*2)+(1*7)=171
171 % 10 = 1
So 169545-27-1 is a valid CAS Registry Number.
InChI:InChI=1/C36H35N3O4/c1-23-17-24(2)19-28(18-23)35(41)39(3)33(20-25-13-15-27(16-14-25)26-9-5-4-6-10-26)34(40)38-32(36(42)43)21-29-22-37-31-12-8-7-11-30(29)31/h4-19,22,32-33,37H,20-21H2,1-3H3,(H,38,40)(H,42,43)/t32-,33+/m0/s1
169545-27-1Relevant articles and documents
BISAMIDE COMPOUNDS AS ALLOSTERIC EFFECTORS FOR REDUCING THE OXYGEN-BINDING AFFINITY OF HEMOGLOBIN
-
, (2015/07/23)
This invention relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof, which are allosteric effectors that reduce the oxygen-binding affinity of hemoglobin, which can enhance the efficacy of radiation therapy for cancer and which are useful for the treatment of ischemia and other conditions.
IRL 2500: A potent ET(B) selective endothelin antagonist
Frueh,Saika,Svensson,Pitterna,Sakaki,Okada,Urade,Oda,Fujitani,Takimoto,Yamamura,Inui,Makatani,Takai,Umemura,Teno,Toh,Hayakawa,Murata
, p. 2323 - 2328 (2007/10/03)
Combination of a glycine substitution scan on the C-terminal dodecapeptide analog of ET-1 and a substance P antagonist screen on the basis of a homology study of the rhodopsin superfamily of seven-transmembrane receptors yielded in the development of IRL 2500, a potent ET(B) selective endothelin antagonist.
