169674-57-1

Basic information

• Product Name: 5-CHLORO-6-FLUOROINDOLE
• Synonyms: 5-CHLORO-6-FLUOROINDOLE
• CAS NO: 169674-57-1
• Molecular Formula: C₈H₅ClFN
• Molecular Weight: 169.58
• Mol File: 169674-57-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 299.8°Cat760mmHg
• Flash Point: 135.1°C
• Appearance: /
• Density: 1.436g/cm³
• Vapor Pressure: 1.11mmHg at 25°C
• Refractive Index: 1.495
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5-CHLORO-6-FLUOROINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-6-FLUOROINDOLE(169674-57-1)
• EPA Substance Registry System: 5-CHLORO-6-FLUOROINDOLE(169674-57-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 169674-57-1(Hazardous Substances Data)

Usage

General Description

5-CHLORO-6-FLUOROINDOLE is a chemical compound with the formula C8H5ClFN. It is a heterocyclic organic compound that contains a five-membered ring with two carbon atoms, one nitrogen atom, and two halogen atoms. 5-CHLORO-6-FLUOROINDOLE is commonly used in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals due to its unique structural and electronic properties. It has also been studied for its potential biological activities, including as an inhibitor for certain enzymes and as a building block for designing new drug candidates. Overall, 5-CHLORO-6-FLUOROINDOLE holds promise for various industrial and medicinal applications and is an important target for chemical research and development.

InChI:InChI=1/C7H5F3OS/c8-7(9,10)11-5-1-3-6(12)4-2-5/h1-4,12H

Upstream product

• 169674-53-7 methyl α-azido-3-chloro-4-fluorocinnamate 
• 169674-55-9 5-chloro-6-fluoro-indole-2-carboxylic acid 
• 1097107-68-0 (4-chloro-5-fluoro-2-trimethylsilanylethynyl-phenyl)-carbamic acid methyl ester 
• 875305-49-0 methyl (4-chloro-5-fluoro-2-iodophenyl)carbamate 
• 1066-54-2 trimethylsilylacetylene 
• 947380-15-6 sodium 1-acetyl-6-fluoro-1H-indole-2-sulfonate 

Downstream Products

• 905953-15-3 4-(5-chloro-6-fluoroindol-3-yl)-6-acetoxy-7-methoxyquinazoline 
• 399-51-9 6-fluoro-1H-indole 
• 1404537-07-0 [4-(4-butyryl-5-methyl-pyrazol-1-yl)phenyl]-5-chloro-6-fluoro-1-[2-(4-methyl-piperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride 
• 1404533-17-0 {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-chloro-6-fluoro-indol-1-yl}acetic acid 
• 1404531-71-0 {3-[4-(4-butyryl-5-methyl-pyrazol-1-yl)phenylcarbamoyl]-5-chloro-6-fluoro-indol-1-yl}acetic acid methyl ester 

Relevant articles and documents

INDOLOPYRIDINES AS INHIBITORS OF THE KINESIN SPINDLE PROTEIN (EG5 )

Compounds of formula (I), in which R1, R2, R3 and R4 have the meanings indicated in the description, are effective Eg5-inhibiting compounds with anti-proliferative and/or apoptosis inducing activity.

Syntheses of 4-(indole-3-yl)quinazolines - A new class of epidermal growth factor receptor tyrosine kinase inhibitors

The epidermal growth factor (EGF) family of membrane receptors has been identified as a key element in the complex signaling network that is utilized by various classes of cell-surface receptors. The synthesis and pharmacological results of 4-(indole-3-yl)quinazolines are described. The synthesized compounds are new high potent EGFR-tyrosine kinase inhibitors with excellent cytotoxic properties at different cell lines. Furthermore the 4-(indole-3-yl)quinazolines show some tendencies to inhibit the HER-2 TK, too. Moreover this substance class has remarkable strong fluorescence properties.

INDOLOPYRIDINES AS EG5 KINESIN MODULATORS

Compounds of a certain formula (I), in which R1, R2, R3, R4, R5 and R6 have the meanings indicated in the description, are effective compounds with anti-proliferative and/or apoptosis inducing activity.