169750-99-6

Basic information

• Product Name: (3S)-(+)-1-BENZYL-3-(ETHYLAMINO)PYRROLIDINE
• Synonyms: (3S)-(+)-1-BENZYL-3-(ETHYLAMINO)PYRROLIDINE;(S)-1-Benzyl-3-(ethylamino)pyrrolidine;(S)-1-Benzyl-N-ethylpyrrolidin-3-aMine;(3S)-(+)-1-Benzyl-3-(ethylamino)pyrrolidine
• CAS NO: 169750-99-6
• Molecular Formula: C13H20N2
• Molecular Weight: 204.31
• Product Categories: 3-Aminopyrrolidines;Amines (Chiral);Chiral 3-Aminopyrrolidines;Chiral Building Blocks;Synthetic Organic Chemistry
• Mol File: 169750-99-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 290.491 °C at 760 mmHg
• Flash Point: 108.666 °C
• Appearance: /
• Density: 0.98
• Vapor Pressure: 0.00206mmHg at 25°C
• Refractive Index: 8 ° (C=10, EtOH)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (3S)-(+)-1-BENZYL-3-(ETHYLAMINO)PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (3S)-(+)-1-BENZYL-3-(ETHYLAMINO)PYRROLIDINE(169750-99-6)
• EPA Substance Registry System: (3S)-(+)-1-BENZYL-3-(ETHYLAMINO)PYRROLIDINE(169750-99-6)

Safety Data

• RIDADR: 2735
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 169750-99-6(Hazardous Substances Data)

Usage

General Description

"(3S)-(+)-1-Benzyl-3-(ethylamino)pyrrolidine" is a chemical compound with a molecular formula of C15H22N2. It is a chiral compound with a three-dimensional structure, and the (3S)-(+)-enantiomer has specific optical rotation properties. (3S)-(+)-1-BENZYL-3-(ETHYLAMINO)PYRROLIDINE contains a pyrrolidine ring with a benzyl group and an ethylamino group attached to it. It is commonly used in organic synthesis and chemical research as a building block for the creation of other more complex compounds. It may also have potential applications in the development of pharmaceutical drugs and other industrial processes due to its unique chemical structure and properties.

InChI:InChI=1/C13H20N2/c1-2-14-13-8-9-15(11-13)10-12-6-4-3-5-7-12/h3-7,13-14H,2,8-11H2,1H3/t13-/m0/s1

Upstream product

• 114715-39-8 (R)-1-benzyl-3-aminopyrrolidine 
• 114636-33-8 (R)-N-(1-benzylpyrrolidine-3-yl)acetamide 

Downstream Products

• 381670-30-0 (R)-3-ethylaminopyrrolidine 
• 1307686-02-7 (+/-)-N-(1-benzylpyrrolidin-3-yl)-2-(3,4-dichlorophenyl)-N-ethylacetamide 
• 1307686-00-5 (+/-)-N-(1-benzylpyrrolidin-3-yl)-1-(3,4-dichlorophenyl)-N-ethylmethanesulfonamide 
• 1307684-29-2 (+/-)-4-fluorophenyl 1-benzylpyrrolidin-3-yl(ethyl)carbamate 

Relevant articles and documents

Development of selective inhibitors for the treatment of rheumatoid arthritis: (R)-3-(3-(Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)-3-oxopropanenitrile as a JAK1-selective inhibitor

A series of 3(R)-aminopyrrolidine derivatives were designed and synthesized for JAK1-selective inhibitors through the modification of tofacitinib's core structure, (3R,4R)-3-amino-4-methylpiperidine. From the new core structures, we selected (R)-N-methyl-N-(pyrrolidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine as a scaffold for further SAR studies. From biochemical enzyme assays and liver microsomal stability tests, (R)-3-(3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)pyrrolidin-1-yl)-3-oxopropanenitrile (6) was chosen for further in vivo test through oral administration. Compound 6 showed improved selectivity for JAK1 compared to that of tofacitinib (IC50 11, 2.4 × 102, 2.8 × 103, and 1.1 × 102 nM for JAK1, JAK2, JAK3, and TYK2, respectively). In CIA and AIA model tests, compound 6 exhibited similar efficacy to tofacitinib citrate.

BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS

The invention provides novel bis-pyridylpyridones which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), pharmaceutical compositions containing them, processes for their preparation, and their use in therapy and for the treatment of obesity and/or diabetes.