169897-99-8

Basic information

• Product Name: (2R,3R,5S)-(t-butyl)-[2-methyl-3-(benzyloxy)-5-[2-(benzyloxy)ethyl]-7-octenyloxy]diphenylsilane
• Synonyms: (2R,3R,5S)-(t-butyl)-[2-methyl-3-(benzyloxy)-5-[2-(benzyloxy)ethyl]-7-octenyloxy]diphenylsilane
• CAS NO: 169897-99-8
• Molecular Weight: 620.948
• Mol File: 169897-99-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2R,3R,5S)-(t-butyl)-[2-methyl-3-(benzyloxy)-5-[2-(benzyloxy)ethyl]-7-octenyloxy]diphenylsilane(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R,5S)-(t-butyl)-[2-methyl-3-(benzyloxy)-5-[2-(benzyloxy)ethyl]-7-octenyloxy]diphenylsilane(169897-99-8)
• EPA Substance Registry System: (2R,3R,5S)-(t-butyl)-[2-methyl-3-(benzyloxy)-5-[2-(benzyloxy)ethyl]-7-octenyloxy]diphenylsilane(169897-99-8)

Safety Data

• Hazardous Substances Data: 169897-99-8(Hazardous Substances Data)

Upstream product

• 81927-55-1 O-benzyl 2,2,2-trichloroacetimidate 
• 169897-98-7 (2R,3R,5S)-1-[[t-butyldiphenylsilyl]-oxy]-2-methyl-5-[2-(benzyloxy)ethyl]-7-octene-3-ol 
• 10385-30-5 4-(benzyloxy)butanoic acid 
• 100-39-0 benzyl bromide 
• 169897-93-2 2S-[2-(benzyloxy)ethyl]-4-pentenal 
• 169897-90-9 (3S-hydroxymethyl-1-(benzyloxy))-5-hexene 
• 169897-95-4 (3S)-[2-(benzyloxyethyl)]-5-hexenal 
• 169897-97-6 (2R,3R,5S)-2-methyl-5-[2-(benzyloxy)ethyl]-7-octene-1,3-diol 
• 544429-65-4 C₁₄H₁₈O₅ 
• 169897-87-4 [4S]-4-benzyl-3-(4-benzyloxy-1-butanoyl)-2-oxazolidinone 
• 169897-88-5 [4S,3(2S)]-4-benzyl-3-(4-benzyloxy-2-allyl-1-butanoyl)-2-oxazolidinone 
• 169897-96-5 [4S,3(2S,3R,5S)]-4-benzyl-3-(5-allyl-6-benzyloxy-3-hydroxy-2-methyl-1-heptanoyl)-2-oxazolidinone 
• 169897-94-3 [(S)-3-((E)-2-Methoxy-vinyl)-hex-5-enyloxymethyl]-benzene 

Downstream Products

• 169898-02-6 ethyl (2E,5S,7R,8R)-9-hydroxy-8-methyl-7-benzyloxy-5-[2-(benzyloxy)ethyl]-2-nonenoate 
• 169898-00-4 (3S,5R,6R)-7-[[t-butyldiphenylsilyl]oxy]-6-methyl-5-benzyloxy-3-[2-(benzyloxy)ethyl]-heptanal 
• 169898-01-5 ethyl (2E,5S,7R,8R)-9-[[t-butyldiphenylsilyl]oxy]-8-methyl-7-benzyloxy-5-[2-(benzyloxy)ethyl]-2-nonenoate 
• 544429-30-3 ethyl (2E,5S,7R,8S)-8-methyl-7-benzyloxy-5-[2-(benzylloxy)ethyl]-9-(methanesulfonyl)-2-nonenoate 
• 544429-29-0 ethyl (2E,5S,7R,8S)-8-methyl-7-benzyloxy-5-[2-(benzyloxy)ethyl]-9-[(2'-benzothiazolyl)sulfonyl]-2-nonenoate 
• 544429-45-0 (2E,9E,11E,18E,20E,22E)-(5S,7R,8R,13S,15R,16S,17R)-7,13-Bis-benzyloxy-5-(2-benzyloxy-ethyl)-15-hydroxy-17-methoxy-8,12,16,18,22-pentamethyl-23-(2-methyl-oxazol-4-yl)-tricosa-2,9,11,18,20,22-hexaenoic acid 

Relevant articles and documents

Enantioselective total synthesis of the antitumor macrolide rhizoxin D

The convergent, highly enantioselective synthesis of rhizoxin D, a natural product possessing potent antitumor and antifungal bioactivity, is described. The C(1)-C(9) fragment of the molecule was synthesized utilizing a threefold pseudosymmetric intermediate ultimately derived from γ-butyrolactone. The central core of rhizoxin D was prepared via a chiral resolution/asymmetric aldol protocol. Several methods for the generation of the polyene fragment were explored, and the side-chain was ultimately prepared from serine in six steps. The unification of the left and right wings of the molecule was achieved using a one-step olefination protocol, and the macrocyclization was carried out using a Horner-Emmons olefination at the C(2)-C(3) olefin.