170019-13-3Relevant articles and documents
Synthesis, biological activity, and absolute stereochemical assignment of NPS 1392: A potent and stereoselective NMDA receptor antagonist
Moe, Scott T.,Shimizu, Scot M.,Smith, Daryl L.,Van Wagenen, Bradford C.,DelMar, Eric G.,Balandrin, Manuel F.,Chien, Yongwei Eric,Raszkiewicz, Joanna L.,Artman, Linda D.,Mueller, Alan L.,Lobkovsky, Emil,Clardy, Jon
, p. 1915 - 1920 (2007/10/03)
The synthesis, biological activity, and single crystal X-ray structure of NPS 1392, (R)-(-)-3,3-bis(3-fluorophenyl)-2-methylpropan-1-amine (3a), a potent, stereoselective antagonist of the NMDA receptor, are described. The NMDA receptor selectively bound