170078-65-6 Usage
General Description
2,3-DI-O-BENZYL-4,6-O-ETHYLIDENE-BETA-D-GLUCOPYRANOSE, also known as DOBEG, is a synthetic chemical compound that belongs to the class of carbohydrates. It is a derivative of glucose and contains two benzyl groups and an ethylidene group attached to the glucose molecule. DOBEG is commonly used as a building block in organic synthesis for the preparation of complex organic molecules. 2,3-DI-O-BENZYL-4,6-O-ETHYLIDENE-BETA-D-GLUCOPYRANOSE has potential applications in the pharmaceutical and agrochemical industries due to its ability to serve as a precursor for the synthesis of bioactive compounds and natural products. Additionally, DOBEG has been studied for its role in the development of new materials and drug delivery systems.
Check Digit Verification of cas no
The CAS Registry Mumber 170078-65-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,0,0,7 and 8 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 170078-65:
(8*1)+(7*7)+(6*0)+(5*0)+(4*7)+(3*8)+(2*6)+(1*5)=126
126 % 10 = 6
So 170078-65-6 is a valid CAS Registry Number.
170078-65-6Relevant articles and documents
Efficient synthesis of the anticancer drug etoposide 4′-phosphate: Use of benzylic ether-protecting groups on the carbohydrate segment
Silverberg, Lee J.,Dillon, John L.,Vemishetti, Purushotham,Sleezer, Paul D.,Discordia, Robert P.,Hartung, Kerry B.,Gao, Qi
, p. 34 - 42 (2013/09/07)
The prodrug etoposide phosphate 2 is synthesized efficiently in three steps in 54.6% overall yield from 4′-demethylepipodophyllotoxin 3. The strategy pursued in the synthesis of 2 places the phosphate on 3 prior to coupling with the sugar and employs benzyl ether-protecting groups on both the phosphate and the sugar, allowing easy removal in one step. The importance of solvent, steric effects, and electronic effects in the coupling reaction is demonstrated. Two features of the synthesis are an unusual thermal anomerization of the carbohydrate component 5a and completely diastereoselective, one-pot crystallization of the coupled product 6a-β. The process has been demonstrated on multi-kilogram scale.
