17015-63-3Relevant articles and documents
Damodaran,Dev
, p. 2897 (1967)
Regioselective molybdenum-catalyzed allylic substitution of tertiary allylic electrophiles: Methodology development and applications
Khan, Ajmal,Khan, Shahid,Salman, Muhammad,Xu, Yaoyao,Zhang, Junjie
, p. 5481 - 5486 (2020/06/10)
The first molybdenum-catalyzed allylic sulfonylation of tertiary allylic electrophiles is described. The method employs a readily accessible catalyst (Mo(CO)6/2,2′-bipyridine, both are commercially available) and represents the first example of the use of a group 6 transition metal-catalyst for allylic sulfonylation of substituted tertiary allylic electrophiles to form carbon-sulfur bonds. This atom economic and operationally simple methodology is characterized by its relatively mild conditions, wide substrate scope, and excellent regioselectivity profile, thus unlocking a new platform to forge sulfone moieties, even in the context of late-stage functionalization and providing ample opportunities for further derivatization through traditional Suzuki cross-coupling reactions.
Anti-proliferative evaluation of monoterpene derivatives against leukemia
Gautam, Lekh Nath,Ling, Taotao,Lang, Walter,Rivas, Fatima
supporting information, p. 75 - 80 (2016/03/01)
The cure rate of pediatric acute lymphoblastic leukemia (ALL) has significantly improved in the past thirty years, however not all patient cohorts respond well to current chemotherapy regimens. Among the high risk patient cohort is infants with MLL-rearranged (MLL-r) B-ALL, which remains dismal with an overall survival rate 35%. Our program is interested in identifying new molecular scaffolds to better understand the underlying mechanisms and ultimately provide new targeted treatments. Based on a phenotypic screen, phenolic natural products were identified as promising scaffolds for further chemical evaluation. Herein we disclose the effects of a potent anti-proliferative compound 31 against human ALL leukemia cellular models.