170210-49-8

Basic information

• Product Name: 1,3-Dioxolane-4-methanol, 2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-, (2S,4R)-
• CAS NO: 170210-49-8
• Molecular Formula: C14H14Cl2N2O3
• Molecular Weight: 329.183
• Mol File: 170210-49-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,3-Dioxolane-4-methanol, 2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-, (2S,4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxolane-4-methanol, 2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-, (2S,4R)-(170210-49-8)
• EPA Substance Registry System: 1,3-Dioxolane-4-methanol, 2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-, (2S,4R)-(170210-49-8)

Safety Data

• Hazardous Substances Data: 170210-49-8(Hazardous Substances Data)

Usage

Chirality

Chiral molecule

Configuration

2S,4R

Functional Group

Imidazole

Enzyme Inhibition

Inhibits certain enzymes involved in fungal cell wall synthesis

Antifungal Medications

Due to its enzyme inhibition properties

Treatment of Fungal Infections

Implies potential use due to the presence of the imidazole functional group

Research Status

Further research is needed to fully understand the implications and potential applications of this chemical compound.

Upstream product

• 288-32-4 1H-imidazole 
• 67-66-3 chloroform 
• 512791-61-6 cis-2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-methanol 

Downstream Products

• 170210-50-1 (2S,4S)-(i)-<2-(2,4-dichlorophenyl)-2-<(1H-imidazol-1-yl)methyl>-1,3-dioxolan-4-yl>methyl methanesulfonate 
• 345649-43-6 (2RS,4SR)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulfonate 
• 65277-42-1 ketoconazole 

Relevant articles and documents

Stereoselective Syntheses of Both Enantiomers of Ketoconazole from (R)- and (S)-Epichlorohydrin

Stereoselective syntheses of both enantiomers of ketoconazole (1) from commercially available (R)- or (S)-epichlorohydrin has been developed.The key-step of syntheses involves the selective substitution of the methylene chlorine atom by benzoate on a mixture of (2S,4R)-14a and (2R,4R)-15a or of their enentiomers, followed by crystalization of the corresponding cis-benzoates, (2R,4R)-18 or (2S,4S)-18, from which (+)- or (-)-1 were obtained as described for (+/-)-1.The ee's of (+)- and (-)-ketocanazole were determined by HPLC on the CSP Chiracel OD-H.

1-(2-Ar-4-aryloxymethyl-1,3-dioxolan-2-ylmethyl)imidazoles

1-(2-Ar-4-aryloxymethyl-1,3-dioxolan-2-ylmethyl)imidazoles, useful as antifungal and antibacterial agents.