17024-55-4

Basic information

• Product Name: 1-(1-methyl-4-nitro-1H-imidazol-5-yl)piperidine
• Synonyms: 1-(1-Methyl-4-nitro-1H-imidazol-5-yl)piperidine; Piperidine, 1-(1-methyl-4-nitro-1H-imidazol-5-yl)-
• CAS NO: 17024-55-4
• Molecular Formula: C₉H₁₄N₄O₂
• Molecular Weight: 210.2331
• Mol File: 17024-55-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 426.4°C at 760 mmHg
• Flash Point: 211.7°C
• Density: 1.38g/cm³
• Vapor Pressure: 1.78E-07mmHg at 25°C
• Refractive Index: 1.652
• CAS DataBase Reference: 1-(1-methyl-4-nitro-1H-imidazol-5-yl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-methyl-4-nitro-1H-imidazol-5-yl)piperidine(17024-55-4)
• EPA Substance Registry System: 1-(1-methyl-4-nitro-1H-imidazol-5-yl)piperidine(17024-55-4)

Safety Data

• Hazardous Substances Data: 17024-55-4(Hazardous Substances Data)

Usage

Description

1-(1-methyl-4-nitro-1H-imidazol-5-yl)piperidine is a chemical compound characterized by a piperidine ring attached to a methyl-nitro-imidazole moiety. It is known for its potential pharmacological activities, such as antiparasitic and antifungal properties, and is considered a valuable starting material in the development of new drugs. Its molecular structure suggests possible biological activity as a neurotransmitter, making it a subject of interest for therapeutic applications in neurological disorders. Furthermore, it has been explored for its potential as an insecticide and in the development of crop protection agents.

Uses

Used in Pharmaceutical Industry:
1-(1-methyl-4-nitro-1H-imidazol-5-yl)piperidine is used as a building block for the synthesis of pharmaceutical drugs due to its potential pharmacological activities, including antiparasitic and antifungal properties. Its versatile molecular structure allows for its incorporation into various drug candidates, enhancing their therapeutic potential.
Used in Agrochemical Industry:
1-(1-methyl-4-nitro-1H-imidazol-5-yl)piperidine is used as a starting material in the development of agrochemicals, specifically as a potential insecticide and in the creation of crop protection agents. Its chemical properties make it a promising candidate for improving pest control and crop yield.
Used in Neuroscience Research:
1-(1-methyl-4-nitro-1H-imidazol-5-yl)piperidine is used as a potential therapeutic agent for neurological disorders. Its molecular structure suggests that it may have biological activity as a neurotransmitter, which could lead to the development of new treatments for various neurological conditions.
Overall, 1-(1-methyl-4-nitro-1H-imidazol-5-yl)piperidine is a versatile chemical compound with potential applications in various fields, including medicine, agriculture, and neuroscience. Its diverse uses and properties make it a valuable asset in the development of new drugs, agrochemicals, and therapeutic agents.

Upstream product

• 110-89-4 piperidine 
• 19183-15-4 1-methyl-4,5-dinitro-1H-imidazole 
• 35681-63-1 5-Iodo-1-methyl-4-nitroimidazole 
• 933-87-9 1-methyl-5-bromo-4-nitro-1H-imidazole 
• 4897-25-0 5-chloro-1-methyl-4-nitroimidazole 

Relevant articles and documents

Room-Temperature Amination of Chloroheteroarenes in Water by a Recyclable Copper(II)-Phosphaadamantanium Sulfonate System

Buchwald-Hartwig amination of chloroheteroarenes has been a challenging synthetic process, with very few protocols promoting this important transformation at ambient temperature. The current report discusses about an efficient copper-based catalytic system (Cu/PTABS) for the amination of chloroheteroarenes at ambient temperature in water as the sole reaction solvent, a combination that is first to be reported. A wide variety of chloroheteroarenes could be coupled efficiently with primary and secondary amines as well as selected amino acid esters under mild reaction conditions. Catalytic efficiency of the developed protocol also promotes late-stage functionalization of active pharmaceutical ingredients (APIs) such as antibiotics (floxacins) and anticancer drugs. The catalytic system also performs efficiently at a very low concentration of 0.0001 mol % (TON = 980,000) and can be recycled 12 times without any appreciable loss in activity. Theoretical calculations reveal that the π-acceptor ability of the ligand PTABS is the main reason for the appreciably high reactivity of the catalytic system. Preliminary characterization of the catalytic species in the reaction was carried out using UV-VIS and ESR spectroscopy, providing evidence for the Cu(II) oxidation state.

Synthesis of 1-methyl-4-nitro-5-substituted-imidazole and substituted imidazolothiazole derivates as possible antiparasitic agents

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