17041-46-2

Basic information

• Product Name: ETHYL COUMARATE
• Synonyms: ETHYL P-HYDROXYCINNAMATE;ETHYL COUMARATE;ETHYL 4-HYDROXYCINNAMATE;ETHYL 4-COUMARATE;P-Hydroxyl ethyl cinnamate;3-(2-Hydroxyphenyl)-2-propenoic acid ethyl ester;Ethyl 2-hydroxycinnamate;Ethyl 3-(2-hydroxyphenyl)acrylate
• CAS NO: 17041-46-2
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.21
• Product Categories: Aromatic Esters
• Mol File: 17041-46-2.mol
• Article Data: 64

Chemical Properties

• Melting Point: 65-68°C
• Boiling Point: 322℃
• Flash Point: 137℃
• Appearance: /
• Density: 1.162
• Refractive Index: 1.4600 (estimate)
• PKA: 8.54±0.30(Predicted)
• CAS DataBase Reference: ETHYL COUMARATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL COUMARATE(17041-46-2)
• EPA Substance Registry System: ETHYL COUMARATE(17041-46-2)

Safety Data

• Hazardous Substances Data: 17041-46-2(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 26, p. 53, 1985 DOI: 10.1016/S0040-4039(00)98464-8

Upstream product

• 89-95-2 2-methyl-benzyl alcohol 
• 105-36-2 ethyl bromoacetate 
• 533-58-4 2-Iodophenol 
• 140-88-5 ethyl acrylate 
• 64-17-5 ethanol 
• 91-64-5 coumarin 
• 141-52-6 sodium ethanolate 
• 90-02-8 salicylaldehyde 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 1009307-13-4 ethyl (2E)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)acrylate 
• 95-56-7 2-hydroxybromobenzene 
• 623-47-2 propynoic acid ethyl ester 
• 108-95-2 phenol 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 70326-80-6 ethyl (E)-3-(2-ethoxyphenyl)propionate 
• 91-64-5 coumarin 
• 15185-05-4 4-phenylcoumarin 
• 1415475-15-8 4-(3,4,5-trimethoxyphenyl)-2H-chromen-2-one 
• 20921-04-4 ethyl 3-(2-hydroxyphenyl)propanoate 
• 3199-61-9 ethyl coumarilate 

Relevant articles and documents

One-pot cascade synthesis of 2,3-disubstituted 2,3-dihydrobenzofurans via ortho-quinone methide intermediates generated in situ

A simple and efficient one-pot cascade reaction for the regioselective synthesis of trans or cis/trans 2,3-disubstituted 2,3-dihydrobenzofurans is reported. The method involves fluoride-induced desilylation, generation of o-quinone methide (o-QM) by chloride or nitrate anion elimination, Michael addition and intramolecular 5-exo-tet elimination of a bromide anion. Nitrate, acetoxy and chloride anions are compared as leaving groups in the formation of the in situ generated o-QM.

Free radical scavenging and α-glucosidase inhibitory activity of (E)-methyl/ethyl-3-(2-hydroxyphenyl)acrylates

(E)-Methyl/ethyl-3-(2-hydroxyphenyl)acrylates 3a-x have been prepared by the reaction of salicylaldehydes 1a-l with Wittig reagents such as methyl (triphenylphosphoranylidene)acetate 2a and ethyl (triphenylphosphoranylidene)acetate 2b in dry DCM at room t

Platinum complex containing diphosphine meta-position carborane ligand and preparation method and application of platinum complex

The invention relates to a platinum complex containing a diphosphine m-carborane ligand and a preparation method and application of the platinum complex, the method of the platinum complex comprises the following steps: reacting n-BuLi with m-carborane m-

Coumarins by Direct Annulation: β-Borylacrylates as Ambiphilic C3-Synthons

Modular β-borylacrylates have been validated as programmable, ambiphilic C3-synthons in the cascade annulation of 2-halo-phenol derivatives to generate structurally and electronically diverse coumarins. Key to this [3+3] disconnection is the BPin unit which serves a dual purpose as both a traceless linker for C(sp2)–C(sp2) coupling, and as a chromophore extension to enable inversion of the alkene geometry via selective energy transfer catalysis. Mild isomerisation is a pre-condition to access 3-substituted coumarins and provides a handle for divergence. The method is showcased in the synthesis of representative natural products that contain this venerable chemotype. Facile entry into π-expanded estrone derivatives modified at the A-ring is disclosed to demonstrate the potential of the method in bioassay development or in drug repurposing.