170649-28-2Relevant articles and documents
Total synthesis of virgatolide B
Hume, Paul A.,Furkert, Daniel P.,Brimble, Margaret A.
supporting information, p. 4588 - 4591 (2013/09/24)
The first total synthesis of the benzannulated spiroketal virgatolide A is presented. Key features include sp3-sp2 Suzuki coupling of an enantiomerically enriched β-trifluoroboratoamide and an aryl bromide, regioselective intramolecular carboalkoxylation, and a 1,3-anti-selective Mukaiyama aldol reaction followed by global deprotection/cyclization with regioselectivity governed by internal hydrogen bonding.
Asymmetric synthesis of (+)-chloriolide
Das, Tapas,Jana, Nandan,Nanda, Samik
scheme or table, p. 2644 - 2647 (2010/06/16)
An asymmetric synthesis of 12-membered ring macrolide, chloriolide has been accomplished by adopting a linear strategy. Lipase-catalyzed enzymatic kinetic resolution (EKR), asymmetric alkynylation using Trost pro-phenol catalyst followed by Yamaguchi macr
Natural product-guided synthesis of a spiroacetal collection reveals modulators of tubulin cytoskeleton integrity
Barun, Okram,Kumar, Kamal,Sommer, Stefan,Langerak, Anette,Mayer, Thomas U.,Mueller, Oliver,Waldmann, Herbert
, p. 4773 - 4788 (2007/10/03)
The spiro[5.5]ketal moiety forms the underlying structural skeleton of numerous biologically active natural products. Since simplified but characteristic spiroketals derived from the parent natural products retain biological activity, the spiro[5.5]ketal