170875-43-1

Basic information

• Product Name: 4-N-(<4',6'-3H>-2'-pyridon)yl-6-trifluoromethyl-2,2,3-trimethyl-3-chromene
• CAS NO: 170875-43-1
• Molecular Weight: 339.31
• Mol File: 170875-43-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-N-(<4',6'-3H>-2'-pyridon)yl-6-trifluoromethyl-2,2,3-trimethyl-3-chromene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-N-(<4',6'-3H>-2'-pyridon)yl-6-trifluoromethyl-2,2,3-trimethyl-3-chromene(170875-43-1)
• EPA Substance Registry System: 4-N-(<4',6'-3H>-2'-pyridon)yl-6-trifluoromethyl-2,2,3-trimethyl-3-chromene(170875-43-1)

Safety Data

• Hazardous Substances Data: 170875-43-1(Hazardous Substances Data)

Upstream product

• 170875-39-5 <4,6-3H>-2-pyridone 
• 148430-58-4 6-trifluoromethyl-2,2,3-trimethyl-3,4-dihydro-3,4-epoxy-2H-1-benzopyran 
• 100-85-6 N-benzyl-trimethylammonium hydroxide 

Relevant articles and documents

Synthesis of [4,6-3H]-2-pyridone and [3H]-RS-91309

We describe herein, a novel synthesis of the previously unreported compound, 4,6-dibromo-2-pyridone (3) and its use in the preparation of [3H]-RS-91309, a potassium channel modulator. This key intermediate, (3), was reduced with carrier free tritium gas to furnish [4,6-3H]-2-pyridone (9) having a specific activity of 50 Ci/mmole. Condensation of (9) with epoxide (10), followed by elaboration of the resulting chromene methyl group of (12) gave [3H]-RS-91309 (14) whose specific activity was also 50 Ci/mmole. This chemistry, as well as the solution of several microscale related stoichiometry problems is discussed.