171017-48-4Relevant articles and documents
7-substituted-amino-3-substituted-3-cephem-4-carboxylic acids
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, (2008/06/13)
The invention provides compounds of the formula STR1 wherein X is CH2, S or O; R1 is a 3 position substituent such as hydrogen, hydroxy, halo, trifluoromethyl, C2 F5, C1 -C6 alkyl, C1 -C6 substituted alkyl, C1 -C6 alkenyl, C1 -C6 alkynyl, CH2 O(CO)R', CH2 O(CO)NH2, CO2 R', thio(C1 -C6)alkyl, thio(C1 C6)alkenyl, oxo(C1 -C6)alkyl, phosphine oxide, quaternary ammonium group, substituted or unsubstituted thiazolothio, or oxo(C1 -C6)alkenyl; wherein R' is hydrogen, C1 -C6 alkyl, or C1 -C6 alkenyl; R2 is hydrogen or a carboxy protecting group; R3 is STR2 (CH2)n ; wherein R6 is hydrogen Me, CH2 F, CF3, C2 H5, CH2 CH2 F, CH2 CF3, C2 F5, CH2 CO2 R', CH2 CONH2, C(Me)2 CO2 R', or C(Me)2 CONH2 ; and n is 0-5; R4 is STR3 wherein Z is O, S, NH, or CH2 ; Y is CH or N; and R7 is hydrogen, C1 -C6 alkyl, CONH2, or CO2 R'; and R5 is STR4 wherein R8 is CH, N, COH, CO(C1 -C6 alkyl) CSH, or CNH2 ; and R9 is R8 as defined; said R5 optionally substituted 1-4 times with halo, OH, SH, NH2, NO2, CH3, C2 H5, CO2 R', CONH2, SO3 H, or SO2 NHR'; and salts thereof. Also, pharmaceutical formulations and methods for treating bacterial infections in man or other animals using the above compounds are disclosed.
