17118-80-8

Basic information

• Product Name: DIETHYLPROPARGYLPHOSPHATE
• Synonyms: DIETHYLPROPARGYLPHOSPHATE
• CAS NO: 17118-80-8
• Molecular Formula: C₇H₁₃O₄P
• Molecular Weight: 192.15
• Mol File: 17118-80-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 223.5°Cat760mmHg
• Flash Point: 103.2°C
• Appearance: /
• Density: 1.123g/cm³
• Vapor Pressure: 0.143mmHg at 25°C
• Refractive Index: 1.432
• CAS DataBase Reference: DIETHYLPROPARGYLPHOSPHATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYLPROPARGYLPHOSPHATE(17118-80-8)
• EPA Substance Registry System: DIETHYLPROPARGYLPHOSPHATE(17118-80-8)

Safety Data

• Hazardous Substances Data: 17118-80-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H13O4P/c1-4-7-11-12(8,9-5-2)10-6-3/h1H,5-7H2,2-3H3

Upstream product

• 107-19-7 propargyl alcohol 
• 681035-21-2 (2-oxo-5,5-diphenyl-oxazolidin-3-yl)-phosphonic acid diethyl ester 
• 814-49-3 diethyl chlorophosphate 
• 122-52-1 triethyl phosphite 
• 762-04-9 phosphonic acid diethyl ester 
• 2060-25-5 3-bromoprop-2-yn-1-ol 
• 762-04-9 Diethyl phosphonate 

Downstream Products

• 27907-00-2 dec-1-yn-4-ol 
• 78094-59-4 1,2-decadien-4-ol 
• 1743-36-8 1-phenylbut-3-yn-1-ol 
• 598-02-7 Diethyl phosphate 

Relevant articles and documents

Phenyliodine(III) Bis(trifluoroacetate) Mediated Synthesis of 6-Piperidinylpurine Homo-N-nucleosides Modified with Isoxazolines or Isoxazoles

The room temperature, 1,3-dipolar cycloaddition reactions of the nitrile oxide obtained from (6-piperidin-1-yl-9H-purin-9-yl)acetaldehyde oxime upon phenyliodine(III) bis(trifluoroacetate) treatment with excess unsaturated alcohols as solvent resulted in isoxazoline or isoxazole derivatives in almost quantitative yields. Analogous derivatives were prepared from the reactions of unsaturated phosphates. Preliminary biological tests indicated inhibition of lipid peroxidation for some of the examined compounds.

Design, synthesis and in vitro biological evaluation of a novel class of anti-adenovirus agents based on 3-amino-1,2-propanediol

Nowadays there is not an effective drug for the treatment of infections caused by human adenovirus (HAdV) which supposes a clinical challenge, especially for paediatric and immunosuppressed patients. Here, we describe the design, synthesis and biological evaluation as anti-adenovirus agents of a new library (57 compounds) of diester, monoester and triazole derivatives based on 3-amino-1,2-propanediol skeleton. Seven compounds (17, 20, 26, 34, 44, 60 and 66) were selected based on their high anti-HAdV activity at low micromolar concentration (IC50 from 2.47 to 5.75 μM) and low cytotoxicity (CC50 from 28.70 to >200 μM). In addition, our mechanistic assays revealed that compounds 20 and 44 might be targeting specifically the HAdV DNA replication process, and compound 66 would be targeting HAdV E1A mRNA transcription. For compounds 17, 20, 34 and 60, the mechanism of action seems to be associated with later steps after HAdV DNA replication.

Cross-hetero-dehydrogenative coupling reaction of phosphites: A catalytic metal-free phosphorylation of amines and alcohols

Phosphorylation of amines, alcohols, and sulfoximines are accomplished using molecular iodine as a catalyst and H2O2 as the sole oxidant under mild reaction conditions. This method provides an easy route for synthesizing a variety of phosphoramidates, phosphorus triesters and sulfoximine-derived phosphoramidates which are of biological importance.