171193-35-4

Basic information

• Product Name: ethyl 1-(pyridin-2-yl)-1H-pyrazole-4-carboxylate
• Synonyms: ethyl 1-(pyridin-2-yl)-1H-pyrazole-4-carboxylate;1-(Pyridin-2-yl)-1H-pyrazole-4-carboxylic acid ethyl ester;1-(2-pyridinyl)-1H-Pyrazole-4-carboxylic acid ethyl ester;Ethyl 1-(2-pyridyl)pyrazole-4-carboxylate
• CAS NO: 171193-35-4
• Molecular Formula: C11H11N3O2
• Molecular Weight: 217.22394
• Mol File: 171193-35-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 354.026 °C at 760 mmHg
• Flash Point: 167.909 °C
• Appearance: /
• Density: 1.236g/cm³
• Storage Temp.: 2-8°C
• PKA: 0.82±0.19(Predicted)
• CAS DataBase Reference: ethyl 1-(pyridin-2-yl)-1H-pyrazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1-(pyridin-2-yl)-1H-pyrazole-4-carboxylate(171193-35-4)
• EPA Substance Registry System: ethyl 1-(pyridin-2-yl)-1H-pyrazole-4-carboxylate(171193-35-4)

Safety Data

• Hazardous Substances Data: 171193-35-4(Hazardous Substances Data)

Usage

General Description

Ethyl 1-(pyridin-2-yl)-1H-pyrazole-4-carboxylate is a chemical compound with a molecular structure consisting of an ethyl group, a pyridine ring, a pyrazole ring, and a carboxylate group. It is widely used in the pharmaceutical industry as a building block for the synthesis of various bioactive molecules, particularly in the development of potential drug candidates. Ethyl 1-(pyridin-2-yl)-1H-pyrazole-4-carboxylate has been identified as a key intermediate in the preparation of pharmaceutical drugs targeting diseases such as cancer, inflammation, and neurological disorders. Its unique structure and reactivity make it a valuable and versatile starting material for the design and synthesis of novel therapeutic agents.

Upstream product

• 37622-90-5 4-ethoxycarbonylpyrazole 
• 372-48-5 2-fluoropyridine 
• 109-04-6 2-bromo-pyridine 
• 109-09-1 2-chloropyridine 
• 4930-98-7 pyrid-2-ylhydrazine 
• 80370-42-9 ethyl 2-formyl-3-oxopropanoate 

Downstream Products

• 886536-48-7 2-(4-(chloromethyl)-1H-pyrazol-1-yl)pyridine 
• 28465-95-4 1-(pyridin-2-yl)-1H-pyrazol-4-amine 
• 77556-50-4 2-(pyrazol-1'-yl)pyridine-4'-carboxylic acid 

Relevant articles and documents

Synthesis of Bidentate Nitrogen Ligands by Rh-Catalyzed C-H Annulation and Their Application to Pd-Catalyzed Aerobic C-H Alkenylation

A new class of bidentate ligands was prepared by a modular approach involving Rh-catalyzed C-H annulation reactions. The resulting conformationally constrained ligands enabled the Pd-catalyzed C-H alkenylation at electron-rich and sterically less hindered positions of electron-rich arenes while promoting the facile oxidation of Pd(0) intermediates by oxygen. This newly introduced ligand class is complementary to the ligands developed for Pd-catalyzed oxidative reactions and may find broad application in transition-metal-catalyzed reactions.

NITROGEN-CONTAINING HETEROARYL DERIVATIVES

The invention is concerned with novel nitrogen-containing heteroaryl derivatives of formula (I) wherein R1, R2, R3, R4, R5, A1, A2, and Y are as defined in the description and in

Certain pyrazoline derivatives with kinase inhibitory activity

The present invention provides certain pyrazoline compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions and methods of using the compositions in the treatment of various diseases.