171595-94-1

Basic information

• Product Name: (2R,5S,7S)-2-(p-methoxyphenyl)-7-methyl-3-oxa-1-azabicyclo<3.3.0>octan-2-one
• Synonyms: (2R,5S,7S)-2-(p-methoxyphenyl)-7-methyl-3-oxa-1-azabicyclo<3.3.0>octan-2-one
• CAS NO: 171595-94-1
• Molecular Weight: 247.294
• Mol File: 171595-94-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,5S,7S)-2-(p-methoxyphenyl)-7-methyl-3-oxa-1-azabicyclo<3.3.0>octan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,5S,7S)-2-(p-methoxyphenyl)-7-methyl-3-oxa-1-azabicyclo<3.3.0>octan-2-one(171595-94-1)
• EPA Substance Registry System: (2R,5S,7S)-2-(p-methoxyphenyl)-7-methyl-3-oxa-1-azabicyclo<3.3.0>octan-2-one(171595-94-1)

Safety Data

• Hazardous Substances Data: 171595-94-1(Hazardous Substances Data)

Upstream product

• 17342-08-4 (S)-Pyroglutaminol 
• 170885-06-0 (2R,5S,7R)-2-(p-methoxyphenyl)-7-(phenylthio)-3-oxa-1-azabicyclo<3.3.0>octan-2-one 
• 170885-07-1 (2R,5S)-2-(p-methoxyphenyl)-3-oxa-1-azabicyclo<3.3.0>oct-6-en-8-one 
• 123-11-5 4-methoxy-benzaldehyde 
• 170885-05-9 (2R,5S)-2-(p-methoxyphenyl)-3-oxa-1-azabicyclo<3.3.0>octan-8-one 
• 74-88-4 methyl iodide 

Downstream Products

• 138078-58-7 (3S,5S)-5-(hydroxymethyl)-3-methyl-2-pyrrolidinone 

Relevant articles and documents

Synthesis of chiral pyrrolidine derivatives from (S)-pyroglutamic acid. I: 7-Substituted (2R,5S)-2-aryl-1-aza-3-oxabicyclo[3.3.0]octan-8-ones, 7- substituted (2R,5S)-2-aryl-1-aza-3-oxabicyclo[3.3.0]oct-6-en-8-ones and 3- substituted (S)-5-(hydroxymethyl)-2-pyrrolidinones

The following chiral pyrrolidine derivatives, 7-substituted (2R,5S)-2- aryl-1-aza-3-oxabicyclo[3.3.0]octan-8-ones (18-24), 7-substituted (2R,5S)-2- aryl-1-aza-3-oxabicyclo[3.3.0]oct-6-en-8-ones (25-29) and 3-substituted (S)- 5-(hydroxymethyl)-2-pyrrolidinones (30-34), were synthesized starting from (S)-pyroglutamic acid and their absolute configurations were determined based on their 1H-NMR spectra.