171800-73-0

Basic information

• Product Name: 1-benzoyl-2-(2-phenylethyl)-2-piperidinecarbonitrile
• Synonyms: 1-benzoyl-2-(2-phenylethyl)-2-piperidinecarbonitrile
• CAS NO: 171800-73-0
• Molecular Weight: 318.418
• Mol File: 171800-73-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-benzoyl-2-(2-phenylethyl)-2-piperidinecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzoyl-2-(2-phenylethyl)-2-piperidinecarbonitrile(171800-73-0)
• EPA Substance Registry System: 1-benzoyl-2-(2-phenylethyl)-2-piperidinecarbonitrile(171800-73-0)

Safety Data

• Hazardous Substances Data: 171800-73-0(Hazardous Substances Data)

Upstream product

• 17376-04-4 2-phenethyl iodide 
• 71413-04-2 (2RS)-1-benzoylpiperidine-2-carbonitrile 
• 78348-46-6 N-benzoyl-2-piperidinecarboxylic acid 

Downstream Products

• 1208110-10-4 (2RS)-1'-[2-(2-methylphenyl)ethyl]-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one hydrochloride 
• 1208110-08-0 (2RS)-1'-[2-(2-methylphenyl)ethyl]-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one 

Relevant articles and documents

Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2′-piperidin)-1-ones as potassium-competitive acid blockers

With the aim to discover a gastric antisecretory agent more potent than the existing proton pump inhibitors, novel 3,4-dihydro-1H-spiro(naphthalene-2,2′-piperidin)-1-one derivatives, which could occupy two important lipophilic pockets (described as LP-1 and LP-2) of H+,K+-ATPase and can strongly bind to the K+-binding site, were designed based on a docking model. Among the compounds synthesized, compound 4d showed a strong H+,K+-ATPase-inhibitory activity and a high stomach concentration in rats, resulting in potent inhibitory action on histamine-stimulated gastric acid secretion in rats. Furthermore, 4d exerted significant inhibitory action on histamine-stimulated gastric-acid secretion in rats with a rapid onset and moderate duration of action after the administration. These findings may lead to a new insight into the drug design of potassium-competitive acid blockers.

Amine compounds, their production and use

A compound of the formula: STR1 wherein Ar 1 and Ar 2 independently represent an optionally substituted aromatic group; P and Q independently represent a divalent aliphatic hydrocarbon group having at least 2 carbon atoms and optionally having either oxygen or sulfur in the carbon chain; R 1 and R 3 independently represent --CO--R, --CONH--R (R represents a hydrocarbon group or a heterocyclic group) or a hydrocarbon group; R 2 and R 4 independently represent hydrogen or an alkyl group; R 2 and R 4 independently represent hydrogen or an alkyl group; R 1 and R 2 or R 3 and R 4, taken together with the adjacent nitrogen atom, may form a nitrogen-containing heterocyclic group; and j represents 0 or 1, or a salt thereof, has excellent GnRH-receptor antagonizing activity and is useful as a prophylactic and therapeutic agent for hormone-dependent and other diseases.