17223-83-5

Basic information

• Product Name: 1-(diphenylcarbamoyl)triaza-1,2-dien-2-ium
• CAS NO: 17223-83-5
• Molecular Formula: C₁₃H₁₀N₄O
• Molecular Weight: 239.2521
• Mol File: 17223-83-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(diphenylcarbamoyl)triaza-1,2-dien-2-ium(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(diphenylcarbamoyl)triaza-1,2-dien-2-ium(17223-83-5)
• EPA Substance Registry System: 1-(diphenylcarbamoyl)triaza-1,2-dien-2-ium(17223-83-5)

Safety Data

• Hazardous Substances Data: 17223-83-5(Hazardous Substances Data)

Usage

Type of Compound

Triazadienyl cation

Substituent

Diphenylcarbamoyl

Applications

a. Organic synthesis
b. Medicinal chemistry

Reactivity

Unique due to diphenylcarbamoyl substituent

Role

Versatile synthetic building block for diverse organic molecules

Potential

Pharmacophore in drug discovery

Structure

Valuable for developing new chemical reactions

Synthesis

Facilitates the creation of complex organic compounds with potential biological activity

Future Research

Could lead to the development of new drugs and materials

Upstream product

• 83-01-2 diphenylcarbamic chloride 
• 603-51-0 N,N-diphenyl semicarbazide 
• 64-19-7 acetic acid 
• 64-17-5 ethanol 
• 603-54-3 N,N-diphenylurea 

Downstream Products

• 6123-91-7 N,N-diphenylcarbamoylpyrrolidine 
• 75534-73-5 piperidine-1-carboxylic acid diphenylamide 
• 75125-45-0 N,N-diphenylmorpholine-4-carboxamide 
• 101586-01-0 morpholine-4-carboxylic acid-(N',N'-diphenyl-hydrazide) 
• 101569-71-5 pyrrole-1-carboxylic acid-(N',N'-diphenyl-hydrazide) 
• 110048-05-0 4-furfuryl-1,1-diphenyl semicarbazide 
• 51616-13-8 3,3-diphenyl-carbazic acid ethyl ester 
• 51616-56-9 1,1,5,5-tetraphenyl carbonohydrazide 
• 101785-10-8 N'-pentyl-N,N-diphenyl-urea 
• 5467-84-5 1,3-diphenethylurea 
• 101279-92-9 3-allyl-1,1-diphenylurea 
• 122-39-4 diphenylamine 
• 28561-80-0 3-hydroxy-1-phenyl-1H-indazole 

Relevant articles and documents

Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase

Database searching and compound screening identified 1-benzyl-3-(3-dimethylaminopropyloxy)-indazole (benzydamine, 3) as a potent activator of the nitric oxide receptor, soluble guanylate cyclase. A comprehensive structure-activity relationship study surrounding 3 clearly showed that the indazole C-3 dimethylaminopropyloxy substituent was critical for enzyme activity. However replacement of the indazole ring of 3 by appropriately substituted pyrazoles maintained enzyme activity. Compounds were evaluated for inhibition of platelet aggregation and showed a general lipophilicity requirement. Aryl-substituted pyrazoles 32, 34, and 43 demonstrated potent activation of soluble guanylate cyclase and potent inhibition of platelet aggregation. Pharmacokinetic studies in rats showed that compound 32 exhibits modest oral bioavailability (12%) Furthermore 32 has an excellent selectivity profile notably showing no significant inhibition of phosphodiesterases or nitric oxide synthases.