17228-38-5

Basic information

• Product Name: 1H-Benzimidazol-2-amine,N-methyl-(9CI)
• Synonyms: 1H-Benzimidazol-2-amine,N-methyl-(9CI);1H-BenziMidazol-2-aMine, N-Methyl-;N-Methyl-1H-benzo[d]iMidazol-2-aMine;N-Methyl-1H-benzimidazol-2-amine
• CAS NO: 17228-38-5
• Molecular Formula: C₈H₉N₃
• Molecular Weight: 147.17716
• Product Categories: BENZIMIDAZOLE
• Mol File: 17228-38-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 190-192℃
• Appearance: /
• Density: 1.284
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 1H-Benzimidazol-2-amine,N-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazol-2-amine,N-methyl-(9CI)(17228-38-5)
• EPA Substance Registry System: 1H-Benzimidazol-2-amine,N-methyl-(9CI)(17228-38-5)

Safety Data

• Hazardous Substances Data: 17228-38-5(Hazardous Substances Data)

Usage

General Description

1H-Benzimidazol-2-amine,N-methyl-(9CI) is a chemical compound with the molecular formula C8H9N3. 1H-Benzimidazol-2-amine,N-methyl-(9CI) is a derivative of benzimidazole, which is a heterocyclic aromatic organic compound. It has a methyl group attached to the nitrogen atom in the benzimidazole ring. 1H-Benzimidazol-2-amine,N-methyl-(9CI) is used in pharmaceutical research and drug development, and it may have potential applications in the treatment of various diseases. Its chemical structure and properties make it a subject of interest for scientists and researchers in the field of medicinal chemistry and drug discovery. However, specific details about its biological activities, potential uses, and safety profile may require further investigation and study.

Upstream product

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Relevant articles and documents

Nucleophilic aromatic substitution of heterocycles using a high-temperature and high-pressure flow reactor

We report herein a high-temperature and high-pressure continuous-flow protocol to carry out nucleophilic aromatic substitution (SNAr) of heterocycles with nitrogen nucleophiles. Utilizing the Phoenix Flow Reactor in parallel with Design-of-Experiment software enabled rapid optimization of the SNAr protocol. This protocol facilitated efficient synthesis of a broad range of 2-aminoquinazolines, and was extended to 2-aminoquinoxalines and 2-aminobenzimidazoles.

CHEMICAL COMPOUNDS

There is provided pyrimidinyl compounds of Formula (I), wherein: R2 is or pharmaceutically acceptable salts thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

OXIDATIVE CYCLIZATION OF 2-AMINO-1-ARYLIDENEAMINOBENZIMIDAZOLES INTO 1,2,4-TRIAZOLOBENZIMIDAZOLES

When heated in nitrobenzene, 1-arylideneamino-2-methylaminobenzimidazoles convert in a 20...30percent yield into 2-aryl-3-methyl-1,2,4-triazolobenzimidazoles.In addition, 2-methylaminobenzimidazole and the corresponding benzonitrile are formed as a result of thermal splitting of the N-N bond.Under the same conditions, 2-amino-1-arylideneaminobenzimidazoles and 1-arylideneamino-3-methylbenzimidazoline-2-imines give only products of splitting off of the nitrile.In several cases, the subsequent reaction of the nitrile with 2-amino-1-methylbenzimidazole leads to the formation of benzamidines.