172659-42-6

Basic information

• Product Name: methyl 2,5-dimethyl-3-oxohexanoate
• Synonyms: methyl 2,5-dimethyl-3-oxohexanoate
• CAS NO: 172659-42-6
• Molecular Weight: 172.224
• Mol File: 172659-42-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 2,5-dimethyl-3-oxohexanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2,5-dimethyl-3-oxohexanoate(172659-42-6)
• EPA Substance Registry System: methyl 2,5-dimethyl-3-oxohexanoate(172659-42-6)

Safety Data

• Hazardous Substances Data: 172659-42-6(Hazardous Substances Data)

Upstream product

• 554-12-1 propanoic acid methyl ester 
• 108-12-3 isopentanoyl chloride 
• 30414-55-2 methyl 5-methyl-3-oxohexanoate 
• 74-88-4 methyl iodide 

Relevant articles and documents

Ti-Crossed-Claisen condensation between carboxylic esters and acid chlorides or acids: A highly selective and general method for the preparation of various β-keto esters

Ti-crossed-Claisen condensation between a 1:1 mixture of carboxylic esters and acid chlorides promoted by TiCl4-Bu3N-N-methylimidazole proceeded successfully to give various β-keto esters in good yields with excellent selectivities (19 examples, ～48-95% yield; cross/self-selectivity = ～96/4-99/1). The present method was extended to the condensation between a 1:1 mixture of carboxylic acids and carboxylic esters (six examples, ～70-92% yield; cross/self-selectivity = ～91/9-99/1). To demonstrate the utility of the present two Ti-crossed-Claisen condensations, we performed a couple of efficient short-step syntheses of two natural, representative, and useful perfumes, cis-jasmone and (R)-muscone. Copyright