17273-05-1

Basic information

• Product Name: Benzenamine, N,N-diethyl-4-isocyanato-
• CAS NO: 17273-05-1
• Molecular Formula: C11H14N2O
• Molecular Weight: 190.245
• Mol File: 17273-05-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzenamine, N,N-diethyl-4-isocyanato-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, N,N-diethyl-4-isocyanato-(17273-05-1)
• EPA Substance Registry System: Benzenamine, N,N-diethyl-4-isocyanato-(17273-05-1)

Safety Data

• Hazardous Substances Data: 17273-05-1(Hazardous Substances Data)

Upstream product

• 530-62-1 1,1'-carbonyldiimidazole 
• 93-05-0 N,N-diethylaniline 
• 75-44-5 phosgene 

Downstream Products

• 56914-26-2 1-(4-pyridylmethyl)-3-(p-diethylaminophenyl)urea 
• 17273-13-1 N-<4-Diethylamino-phenyl>-thiolcarbaminsaeure-<4-(N,N-bis-(2-chlor-ethyl)-amino)-phenylester> 
• 101603-42-3 N-(4-Amino-phenyl)-N'-(4-diethylamino-phenyl)-harnstoff 
• 101578-24-9 N-<4-Diethylamino-phenyl>-N'-<4-hydroxy-phenyl>-harnstoff 
• 47590-33-0 N-(4-N,N-Diethylamino-phenyl)-carbaminsaeure-4--phenylester 

Relevant articles and documents

Phenylquinoline transient receptor potential vanilloid 1 antagonists for the treatment of pain: Discovery of 1-(2-phenylquinoline-4-carbonyl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide

Reported herein is the design, synthesis, and pharmacologic characterization of a class of TRPV1 antagonists constructed on a phenylquinoline platform that evolved from Cinchophen lead. This design composes three sections: a phenylquinoline headgroup attached to an aliphatic carboxamides, which is tethered at a phenyl tail group. Optimization of this design led to the identification of 37, comprising a pyrrolidine linker and a trifluoromethyl–phenyl tail. In the TRPV1 functional assay, using cells expressed hTRPV1, 37 antagonized capsaicin-induced Ca2+ influx, with an IC50 value of 10.2 nM. In the complete mice analgesic model, 37 exhibited better antinociceptive activity than the positive control BCTC in diverse pain models. All of these results suggested that 37 could be considered as a lead candidate for the further development of antinociceptive drugs.