172738-60-2

Basic information

• Product Name: Benzenesulfonamide, 4-methoxy-N-(2-methylpropyl)-
• Synonyms: N-Isobutyl-4-methoxy-benzenesulfonamide;N-iso-butyl-4-methoxybenzenesulfonamide
• CAS NO: 172738-60-2
• Molecular Formula: C11H17NO3S
• Molecular Weight: 243.327
• Mol File: 172738-60-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, 4-methoxy-N-(2-methylpropyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, 4-methoxy-N-(2-methylpropyl)-(172738-60-2)
• EPA Substance Registry System: Benzenesulfonamide, 4-methoxy-N-(2-methylpropyl)-(172738-60-2)

Safety Data

• Hazardous Substances Data: 172738-60-2(Hazardous Substances Data)

Upstream product

• 78-81-9 isobutylamine 
• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 
• 696-63-9 4-Methoxybenzenethiol 

Downstream Products

• 1613304-80-5 N-(4-chlorobenzyl)-N-isobutyl-4-methoxybenzenesulfonamide 
• 1613304-81-6 N-(4-chlorobenzyl)-4-hydroxy-N-isobutylbenzenesulfonamide 
• 1027870-37-6 [(4-Cyclohexylmethoxy-benzenesulfonyl)-isobutyl-amino]-acetic acid ethyl ester 
• 161315-33-9 ethyl 2-[[4-hexyloxybenzenesulfonyl](isobutyl)amino]acetate 
• 1027905-16-3 {[4-(2-Ethoxy-ethoxy)-benzenesulfonyl]-isobutyl-amino}-acetic acid ethyl ester 
• 1026649-42-2 {Isobutyl-[4-(3-methyl-butoxy)-benzenesulfonyl]-amino}-acetic acid ethyl ester 
• 1027323-89-2 [Isobutyl-(4-isopropoxy-benzenesulfonyl)-amino]-acetic acid ethyl ester 
• 161314-17-6 N-hydroxy-2-[isobutyl-(4-methoxybenzenesulfonyl)amino]acetamide 
• 161315-34-0 ethyl 2-[[4-hydroxybenzenesulfonyl](isobutyl)amino]acetate 
• 177702-12-4 ethyl 2-[[4-methoxybenzenesulfonyl](isobutyl)-amino]acetate 

Relevant articles and documents

BENZENE SULFONAMIDE DERIVATIVES AND THEIR USE AS RORC MODULATORS

Compounds of the formula la or lb: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, D, E, G, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Hydroxamates: Relationships between structure and plasma stability

Hydroxamates are valuable tools for chemical biology as well as interesting leads for medicinal chemistry. Although many hydroxamates display nanomolar activities against metalloproteases, only three hydroxamates have reached the market, among which is the HDAC inhibitor vorinostat. Failures in development are generally attributed to lack of selectivity, toxicity, or poor stability. To help medicinal chemists with respect to plasma stability, we have performed the first and preliminary study on structure-plasma stability for hydroxamates. We define some structural rules to predict or improve the plasma stability in the preclinical stage.

SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE

This invention provides a novel class of sulfonamide compounds of formula I which are aspartyl protease inhibitors: STR1 This invention also provides pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also provides methods for inhibition aspartyl protease activity and methods for treating viral infections using the compounds and compositions of this invention.