17278-57-8Relevant articles and documents
Fabrication of resin supported Au-Pd bimetallic nanoparticle composite to efficiently remove chloramphenicol from water
Wang, Xu,Wang, Yun-Xia,Yuan, Baoling,Cui, Hao-Jie,Fu, Ming-Lai
, p. 18806 - 18812 (2015)
The evolution of antibiotic resistance and the potential impact on human health of chloramphenicol (CAP) have made it an environmental pollutant requiring urgent action. In this study, Au-Pd bimetallic nanoparticles (BNPs) were first synthesized and then successfully loaded on Amberlite 717 to form an Amberlite 717 supported Au-Pd BNP catalytic system (717@Au-Pd) with the mass fraction of Au-Pd at about 4.5%. The as-synthesized catalytic system was used to degrade CAP in water under a H2 atmosphere at room temperature. When 0.5 g of 717@Au-Pd was added into the CAP solution (50 mg L-1, 50 mL, pH 7), about 60% of CAP was absorbed on the 717@Au-Pd in the first 10 h and then all of CAP can be completely removed in the following 3 h under a H2 atmosphere. The degradation process of the reaction can be fitted with a first-order kinetics equation with the kinetics constant of 4.3 h-1 ± 0.009. The degradation products and mechanism were studied using LC/MSD Trap-XCT. The results showed that CAP was removed by the 717@Au-Pd via cleaving the carbon-halogen bond of CAP while keeping the nitro-group unaffected and this made the degradation products less environmentally toxic. The recycled experiments showed that the removal rate of CAP can still be maintained at 99% even after 5 cycles. The study indicated that 717@Au-Pd is a promising catalyst for removing environmental pollutants such as CAP containing carbon-halogen bonds.
Oligonucleotides with (N-thymin-1-ylacetyl)-1-arylserinol backbone: Chiral acyclic analogs with restricted conformational flexibility
Rana, Vipul S,Kumar, Vaijayanti A,Ganesh, Krishna N
, p. 1311 - 1321 (2007/10/03)
All four threoerythro stereoisomers of 2(R/S)-(N-thymin-1-ylacetyl)-amino-1(R/S)-aryl-1,3-propanediol were synthesized from 2(R/S)-amino-1(R/S)-aryl-1,3-propanediol in 45-50% overall yield. The inversion of the C1 hydroxyl group in (1S, 2S), 4a, and (1R, 2R), 4d, was accomplished under Mitsunobu conditions to get (1R, 2S), 4c, and (1S, 2R), 4e isomers, respectively. Compounds 4a-f were individually converted into their respective amidite synthons 5a-f. All these stereoisomers were individually incorporated into oligonucleotides (ODNs) at pre-determined positions and various biophysical studies of their hybrids with complementary DNA were carried out. All the four stereoisomers when present at 3′/5′ terminal positions in the ODNs were almost equally efficient in their binding capacity as the natural oligomers, with (1S, 2S) being marginally favored over other stereoisomers. The incorporation of these chiral acyclic nucleosides also protected the ODN against enzymatic degradation.
